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- 작성자 : 김성수
- 작성일 : 2005-03-29
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경희의대 학생들은 김 박사보다 더 잘 할 수 있을 것으로 믿습니다. 기초의학도 잘하면 매우 보람될 수 있습니다. 경희의대 학생들이 기초의학에 많은 관심을 가지고 도전해 주시기 바랍니다.
김자영 (Jayoung Kim)
Harvard Medical School
J. Clin. Invest., Published Online March 17, 2005
Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
Liyan Zhuang 1, Jayoung Kim 1, Rosalyn M. Adam 1, Keith R. Solomon 2, Michael R. Freeman 3*
1 The Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Boston, Massachusetts, USA. Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA. 2 The Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Boston, Massachusetts, USA. Department of Orthopaedic Surgery, Harvard Medical School, Boston, Massachusetts, USA. Department of Orthopaedic Surgery, Children's Hospital Boston, Boston, Massachusetts, USA. 3 John F. Enders Research Laboratories, Suite 1161, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. Phone: (617) 355-6054; Fax: (617) 730-0238
* Address correspondence
Received for publication September 2, 2003, and accepted in revised form February 1, 2005
Abstract
Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in cell membranes that regulate phosphorylation cascades originating from membrane-bound proteins. In this study, we tested whether alteration of the cholesterol content of lipid rafts in prostate cancer (PCa) cell membranes affects cell survival mechanisms in vitro and in vivo. Simvastatin, a cholesterol synthesis inhibitor, lowered raft cholesterol content, inhibited Akt1 serine-threonine kinase (protein kinase B)/protein kinase B (Akt/PKB) pathway signaling, and induced apoptosis in caveolin- and PTEN-negative LNCaP PCa cells. Replenishing cell membranes with cholesterol reversed these inhibitory and apoptotic effects. Cholesterol also potentiated Akt activation in normal prostate epithelial cells, which were resistant to the apoptotic effects of simvastatin. Elevation of circulating cholesterol in SCID mice increased the cholesterol content and the extent of protein tyrosine phosphorylation in lipid rafts isolated from LNCaP/sHB xenograft tumors. Cholesterol elevation also promoted tumor growth, increased phosphorylation of Akt, and reduced apoptosis in the xenografts. Our results implicate membrane cholesterol in Akt signaling in both normal and malignant cells and provide evidence that PCa cells can become dependent on a cholesterol-regulated Akt pathway for cell survival.
저자와의 연락을 원하시면 한빛사 담당자에게 연락주시기 바랍니다.
About the Author
EDUCATION/TRAINING
1998-2001 Ph.D. Kyung Hee University, Korea Cell Biology, Genetic Engineering
1993-1995 M.S. Ulsan University, Korea, Biochemistry, Microbiology
1989-1993 B.S. Ulsan University, Korea, Microbiology
SELECTED PUBLICATIONS
1. Kim, J., Adam, R.M., and Freeman M.R. Trafficking of Nuclear HB-EGF into Epidermal Growth Receptor Dependent Autocrine Loop in Response to Oxidative Stress. Cancer Research (submitted)
2. Kim, J.,* Zhuang, L.,* You, F., Adam, R.M., Solomon, K.R., and Freeman M.R. Cholesterol regulates cell survival in human prostate cancer xenografts. Journal of Clinical Investigation (2005, March 17, Epub ahead of print, *co-first author)
3. Kim, J., Lin, J., Adam, R.M., Lamb, C., Shively, S.B., and Freeman, M.R. (2005) An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding. Journal of Cellular Biochemistry 94(1):39-49.
4. Adam, R.M, Cinar, B., Kim, J.Y., Khoury, J., Danciu, T., Solomon, K.R., Freeman, M.R. Inactivation of Akt/protein kinase B in lipid raft microdomains. Journal of Biological Chemistry (in revision)
5. Kim, J.Y., Adam, R.M., Solomon, K.R., and Freeman, M.R. (2004) Involvement of cholesterol-rich lipid rafts in Interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinology 145:613-619.
6. Kim, J.Y., Freeman, M.R. (2003) JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells. Breast Cancer Research and Treatment 79: 321-328.
7. Adam, R.M., Kim, J.Y., Freeman, M.R. (2002) Heparine-binding EGF-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology 143: 4599-4608.
8. Kim, J.Y., Adam, R.M., and Freeman, M.R. (2002) Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Research 62: 1549-1554.
9. Chen, Y.K., Kim, J.Y., and Kim, S.S. (2000) Phosphatidylinositol 3-kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase. Biochemical and Biophysical Research Communications 276: 502-507.
10. Kim, B.C., Lee, M.N., Kim, J.Y., Chang, J.D., Kim, S.S., Lee, S.Y., and Kim, J.H. (1999) Role of PI3-kinase and Rac in the nuclear signaling by tumor necrosis factors-alpha in Rat-2 fibroblasts. Journal of Biological Chemistry 274: 24372-24377.
11. Kim, J.M., Yoon, M., Kim, J.Y., Kim, S.S., Kang, I., Ha, J., and Kim, S.S. (1999) Phosphatidylinositol 3-kinase regulated differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/ Akt- independent pathway. Archives of Biochemistry and Biophysics 367: 67-73.
12. Park, C.E., Kim, S.M., Kim, J.M., Yoon, M., Kim, J.Y., Kang, I., Kim, S.S. and Ha, J. (1998) Rapid increase of cytosolic contents of acetyl-Co A carboxylase isoforms in H9c2 cells by short term treatment with insulin and okadaic acid. Experimental and Molecular Medicine 30: 73-79.
13. Keum, W.K., Kim, J.Y., Chi, S.G., Woo, H.J., Kim, S.S., Ha, J., and Kang, I. (1998) Heterogeneous HBV mutants coexist in Korean hepatitis B patients. Experimental and Molecular Medicine 30: 115-122.
14. Khil, L.Y., Kim, J.Y., Yoon, J.B., Kim, J.M., Keum, W.K., Kim, T., Yoon, Y., Yoon, M., Moon, C., Lee, J., Ha, J., Kim, S.S. and Kang, I.S. (1997) Insulin Has a Limited Effect on the Cell Cycle Progression in 3T3 L1 Fibroblasts. Molecules and Cells 7: 742-748.
15. Kwak, D.S., Kim, J.Y., Lee, Y.I., and Jung, G.H. (1996) Expression and Purification of Human Hepatitis B Virus Polymerase with a Dual Affinity Tag. Korean Journal of Genetics 18: 131-138.
PRESENTATIONS
1. Kim, J.Y.,* Zhuang, L.Y.*, You, F., Adam, R.M., Solomon, K.R., Freeman, M.R. Cholesterol Regulates Cell Survival in Human Prostate Cancer Xenografts. *, equal contribution. The International Conference on Food, Nutrition and Cancer. Journal of Nutrition, In press.
2. Kim J.Y., Lin, J., Adam, R.M., Lamb, C., Shively, S.B. and Freeman, M.R. (2004) An Oxidative Stress Mechanism Mediates Chelerythrine-induced Heparin-binding EGF-like Growth Factor Ectodomain Shedding. American Association of Cancer Research.
3. Kim, J.Y., Adam, R.M., Solomon, K.R., and Freeman, M.R. (2004) Involvement of cholesterol-rich lipid rafts in Interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Dana-Farber/Harvard Cancer Center Prostate Cancer SPORE Reteat.
4. Kim, J.Y.,* Zhuang, L.Y.*, You, F., Adam, R.M., Solomon, K.R., Freeman, M.R. (2003) Cholesterol Regulates Cell Survival in Human Prostate Cancer Xenografts. Clinical Cancer Research 9, 6178S-6179S Part 2 Suppl. S
5. Adam, R.M., Kim, J.Y., Lin, J.Q., Orsola A., Zhuang L.Y., Rice D.C.,Freeman, M.R. (2003) Heparine-binding EGF-like growth factor (HB-EGF) stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Journal of Urology 169, 156-156 605 Suppl. S
6. Kim, J.Y., Choi, S.L., Khil, L., Kim, J.M., Keum, W.K., Kim, S. J., Ha, J., Kim, S.S., Kang, I. (1999) Activation mechanism of PI-3 Kinase by insulin in 3T3 L1 fibroblasts. Oral presentation. Korean Society of Molecular and Cell Biology, Korea.
7. Ha, J., Kim, J.M., Yoon, M., Kim, J.Y., Kim, S.S., Kang, I. (1998) The role of N-terminus of Acetyl-coA carboxylase isoforms in fatty acid synthesis and oxidation. Conference on Basic Medicine, Korea.
8. Kim, S.S., Kang, I., Ha, J., Kim, J.Y., (1998) The regulatory mechanism of PI3-kinase activity by insulin in 3T3-L1 fibroblasts. Conference on Basic Medicine, Korea.
9. Kang, I., Keum, W.K., Ha, J., Khil, L.Y., Kwak, D.S, Kim, J.Y., Kim, J.M., Back, H.W., Yang, M.H., Chi, S.G., Park, J.H., Kim, S.M., Woo, J.M., Jeong, Y.S., Lee, Y.I., Kim, S.S. (1997) The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients. IUBMB, USA. FASEB Journal 11(9), 3401-.
10. Kim, S.S., Kwak, D.S., Kim, S.T., Keum, W.K., Kim, J.Y., Kim, S.S., Ha, J., Kang, I., Moon, C.K., Khil, L.Y. (1997) The inhibition of phosphatidylinositol 3-kinase by dominant negative mutant p85 subunit induces apoptosis after proliferation to confluency in 3T3-L1 fibroblast. IUBMB, USA. FASEBS Journal 11(9), 2863-.
SELECTED INVITED LECTURES
2003, Yonsei University, Seoul, Korea.
2003, Kyung Hee University, Seoul, Korea.
2003, Korea National Institute of Health, Seoul, Korea.
2003, Korea National Cancer Research Center, Ilsan, Korea.
2003, Wonkwang University, Iksan, Korea.
2003, Myeong Ji University, Yong In, Korea.
2003, New England Biological Society, Harvard Medical School, Boston
2002, New England Biological Society, Harvard Medical School, Boston
2001, New England Biological Society, Harvard Medical School, Boston
OPPOINTMENTS AND RESEARCH POSITIONS
2004-present Associate Scientific Staff/Instructor, Department of Urology, Children's Hospital Boston/ Department of Sergery, Harvard Medical School
2000-2004 Postdoc/Research Fellow, Department of Urology, Harvard Medical School, Children's Hospital Boston
1999-2000 Associate Scientist, Department of Ophthalmology, Yonsei University, Seoul, Korea
1998-1999 Research Associate, East-West Medical Research Center, Kyung Hee University, Seoul, Korea
1998-1999 Teaching Assistant of Molecular Biology, Dept. of Molecular Biology, Kyung Hee University, Seoul, Korea
1996-1998 Research Associate, Research Center for Cell Differentiation, Seoul National University, Seoul, Korea
1995-1996 Research Associate and Teaching Assistant, Sookmyeong Women's University, Seoul, Korea
1993-1995 Research Associate and Teaching Assistant, Ulsan University, Ulsan, Korea
HONORS and AWARDS
2004 Best poster award and Travel award for the AICR/WCRF International Conference on Food, Nutrition and Cancer.
1999 Winner of the Young Scientists Academic Fund, Korean Research Foundation, Seoul, Korea. Project title: The Mechanism in the cardiomyoblasts growth and differentiation by p38MAPK and Phosphatidylinositide (PI)3-kinase.
1998 Graduate Scholarship for Academic Achievement, Kyung Hee University, Korea
1995 Winner of the Young Scientists Academic Fund, Korean Research Foundation, Seoul, Korea. Project title: Purification and characterization of PNP.
1993 Honor Student Award, Ulsan University, Korea
1989-1993 Tuition Grant Scholarship for Merit, Ulsan University, Korea
RESEARCH FUNDING-AWARDED GRANTS
2004-present : American Foundation for Urological Disease Research Scholar (AFUD), USA
PROFESSIONAL AFFILIATIONS
2003-present : Associate member of American Association of Cancer Research (AACR), USA
2000-present : Member of New England Biological Society, USA
LEADERSHIP ROLES
2005- : President-Elect of New Englad BioScience Society (NEBS), USA
2003-2004 : President of Weekly Journal Club in Harvard Medical School, USA
관련사이트 및 보도자료
- The Freeman Lab. http://www.freemanlab.org/news/mar19.htm
- High Cholesterol feeds prostate cancer: High cholesterol levels accelerate the growth of prostate tumors, research has found. BBC News, Friday, 18 March, 2005.
- High cholesterol levels accelerate growth of prostate cancer, Medical News Today 18 Mar 2005.
- High Cholesterol May Speed Prostate Cancer: Lowering Cholesterol Levels May Slow Growth of Prostate Cancer Tumors. Web MD Health, March 18, 2005.
- High Cholesterol Drives Prostate Cancer ABC News, March 19, 2005.
김자영 (Jayoung Kim)
Harvard Medical School
J. Clin. Invest., Published Online March 17, 2005
Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
Liyan Zhuang 1, Jayoung Kim 1, Rosalyn M. Adam 1, Keith R. Solomon 2, Michael R. Freeman 3*
1 The Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Boston, Massachusetts, USA. Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA. 2 The Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Boston, Massachusetts, USA. Department of Orthopaedic Surgery, Harvard Medical School, Boston, Massachusetts, USA. Department of Orthopaedic Surgery, Children's Hospital Boston, Boston, Massachusetts, USA. 3 John F. Enders Research Laboratories, Suite 1161, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. Phone: (617) 355-6054; Fax: (617) 730-0238
* Address correspondence
Received for publication September 2, 2003, and accepted in revised form February 1, 2005
Abstract
Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in cell membranes that regulate phosphorylation cascades originating from membrane-bound proteins. In this study, we tested whether alteration of the cholesterol content of lipid rafts in prostate cancer (PCa) cell membranes affects cell survival mechanisms in vitro and in vivo. Simvastatin, a cholesterol synthesis inhibitor, lowered raft cholesterol content, inhibited Akt1 serine-threonine kinase (protein kinase B)/protein kinase B (Akt/PKB) pathway signaling, and induced apoptosis in caveolin- and PTEN-negative LNCaP PCa cells. Replenishing cell membranes with cholesterol reversed these inhibitory and apoptotic effects. Cholesterol also potentiated Akt activation in normal prostate epithelial cells, which were resistant to the apoptotic effects of simvastatin. Elevation of circulating cholesterol in SCID mice increased the cholesterol content and the extent of protein tyrosine phosphorylation in lipid rafts isolated from LNCaP/sHB xenograft tumors. Cholesterol elevation also promoted tumor growth, increased phosphorylation of Akt, and reduced apoptosis in the xenografts. Our results implicate membrane cholesterol in Akt signaling in both normal and malignant cells and provide evidence that PCa cells can become dependent on a cholesterol-regulated Akt pathway for cell survival.
저자와의 연락을 원하시면 한빛사 담당자에게 연락주시기 바랍니다.
About the Author
EDUCATION/TRAINING
1998-2001 Ph.D. Kyung Hee University, Korea Cell Biology, Genetic Engineering
1993-1995 M.S. Ulsan University, Korea, Biochemistry, Microbiology
1989-1993 B.S. Ulsan University, Korea, Microbiology
SELECTED PUBLICATIONS
1. Kim, J., Adam, R.M., and Freeman M.R. Trafficking of Nuclear HB-EGF into Epidermal Growth Receptor Dependent Autocrine Loop in Response to Oxidative Stress. Cancer Research (submitted)
2. Kim, J.,* Zhuang, L.,* You, F., Adam, R.M., Solomon, K.R., and Freeman M.R. Cholesterol regulates cell survival in human prostate cancer xenografts. Journal of Clinical Investigation (2005, March 17, Epub ahead of print, *co-first author)
3. Kim, J., Lin, J., Adam, R.M., Lamb, C., Shively, S.B., and Freeman, M.R. (2005) An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding. Journal of Cellular Biochemistry 94(1):39-49.
4. Adam, R.M, Cinar, B., Kim, J.Y., Khoury, J., Danciu, T., Solomon, K.R., Freeman, M.R. Inactivation of Akt/protein kinase B in lipid raft microdomains. Journal of Biological Chemistry (in revision)
5. Kim, J.Y., Adam, R.M., Solomon, K.R., and Freeman, M.R. (2004) Involvement of cholesterol-rich lipid rafts in Interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Endocrinology 145:613-619.
6. Kim, J.Y., Freeman, M.R. (2003) JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells. Breast Cancer Research and Treatment 79: 321-328.
7. Adam, R.M., Kim, J.Y., Freeman, M.R. (2002) Heparine-binding EGF-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Endocrinology 143: 4599-4608.
8. Kim, J.Y., Adam, R.M., and Freeman, M.R. (2002) Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation. Cancer Research 62: 1549-1554.
9. Chen, Y.K., Kim, J.Y., and Kim, S.S. (2000) Phosphatidylinositol 3-kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase. Biochemical and Biophysical Research Communications 276: 502-507.
10. Kim, B.C., Lee, M.N., Kim, J.Y., Chang, J.D., Kim, S.S., Lee, S.Y., and Kim, J.H. (1999) Role of PI3-kinase and Rac in the nuclear signaling by tumor necrosis factors-alpha in Rat-2 fibroblasts. Journal of Biological Chemistry 274: 24372-24377.
11. Kim, J.M., Yoon, M., Kim, J.Y., Kim, S.S., Kang, I., Ha, J., and Kim, S.S. (1999) Phosphatidylinositol 3-kinase regulated differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/ Akt- independent pathway. Archives of Biochemistry and Biophysics 367: 67-73.
12. Park, C.E., Kim, S.M., Kim, J.M., Yoon, M., Kim, J.Y., Kang, I., Kim, S.S. and Ha, J. (1998) Rapid increase of cytosolic contents of acetyl-Co A carboxylase isoforms in H9c2 cells by short term treatment with insulin and okadaic acid. Experimental and Molecular Medicine 30: 73-79.
13. Keum, W.K., Kim, J.Y., Chi, S.G., Woo, H.J., Kim, S.S., Ha, J., and Kang, I. (1998) Heterogeneous HBV mutants coexist in Korean hepatitis B patients. Experimental and Molecular Medicine 30: 115-122.
14. Khil, L.Y., Kim, J.Y., Yoon, J.B., Kim, J.M., Keum, W.K., Kim, T., Yoon, Y., Yoon, M., Moon, C., Lee, J., Ha, J., Kim, S.S. and Kang, I.S. (1997) Insulin Has a Limited Effect on the Cell Cycle Progression in 3T3 L1 Fibroblasts. Molecules and Cells 7: 742-748.
15. Kwak, D.S., Kim, J.Y., Lee, Y.I., and Jung, G.H. (1996) Expression and Purification of Human Hepatitis B Virus Polymerase with a Dual Affinity Tag. Korean Journal of Genetics 18: 131-138.
PRESENTATIONS
1. Kim, J.Y.,* Zhuang, L.Y.*, You, F., Adam, R.M., Solomon, K.R., Freeman, M.R. Cholesterol Regulates Cell Survival in Human Prostate Cancer Xenografts. *, equal contribution. The International Conference on Food, Nutrition and Cancer. Journal of Nutrition, In press.
2. Kim J.Y., Lin, J., Adam, R.M., Lamb, C., Shively, S.B. and Freeman, M.R. (2004) An Oxidative Stress Mechanism Mediates Chelerythrine-induced Heparin-binding EGF-like Growth Factor Ectodomain Shedding. American Association of Cancer Research.
3. Kim, J.Y., Adam, R.M., Solomon, K.R., and Freeman, M.R. (2004) Involvement of cholesterol-rich lipid rafts in Interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells. Dana-Farber/Harvard Cancer Center Prostate Cancer SPORE Reteat.
4. Kim, J.Y.,* Zhuang, L.Y.*, You, F., Adam, R.M., Solomon, K.R., Freeman, M.R. (2003) Cholesterol Regulates Cell Survival in Human Prostate Cancer Xenografts. Clinical Cancer Research 9, 6178S-6179S Part 2 Suppl. S
5. Adam, R.M., Kim, J.Y., Lin, J.Q., Orsola A., Zhuang L.Y., Rice D.C.,Freeman, M.R. (2003) Heparine-binding EGF-like growth factor (HB-EGF) stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function. Journal of Urology 169, 156-156 605 Suppl. S
6. Kim, J.Y., Choi, S.L., Khil, L., Kim, J.M., Keum, W.K., Kim, S. J., Ha, J., Kim, S.S., Kang, I. (1999) Activation mechanism of PI-3 Kinase by insulin in 3T3 L1 fibroblasts. Oral presentation. Korean Society of Molecular and Cell Biology, Korea.
7. Ha, J., Kim, J.M., Yoon, M., Kim, J.Y., Kim, S.S., Kang, I. (1998) The role of N-terminus of Acetyl-coA carboxylase isoforms in fatty acid synthesis and oxidation. Conference on Basic Medicine, Korea.
8. Kim, S.S., Kang, I., Ha, J., Kim, J.Y., (1998) The regulatory mechanism of PI3-kinase activity by insulin in 3T3-L1 fibroblasts. Conference on Basic Medicine, Korea.
9. Kang, I., Keum, W.K., Ha, J., Khil, L.Y., Kwak, D.S, Kim, J.Y., Kim, J.M., Back, H.W., Yang, M.H., Chi, S.G., Park, J.H., Kim, S.M., Woo, J.M., Jeong, Y.S., Lee, Y.I., Kim, S.S. (1997) The amount of hepatitis B virus (HBV) DNA has no correlationship with aminotransferases and multiple HBV mutants coexist in chronic hepatitis B patients. IUBMB, USA. FASEB Journal 11(9), 3401-.
10. Kim, S.S., Kwak, D.S., Kim, S.T., Keum, W.K., Kim, J.Y., Kim, S.S., Ha, J., Kang, I., Moon, C.K., Khil, L.Y. (1997) The inhibition of phosphatidylinositol 3-kinase by dominant negative mutant p85 subunit induces apoptosis after proliferation to confluency in 3T3-L1 fibroblast. IUBMB, USA. FASEBS Journal 11(9), 2863-.
SELECTED INVITED LECTURES
2003, Yonsei University, Seoul, Korea.
2003, Kyung Hee University, Seoul, Korea.
2003, Korea National Institute of Health, Seoul, Korea.
2003, Korea National Cancer Research Center, Ilsan, Korea.
2003, Wonkwang University, Iksan, Korea.
2003, Myeong Ji University, Yong In, Korea.
2003, New England Biological Society, Harvard Medical School, Boston
2002, New England Biological Society, Harvard Medical School, Boston
2001, New England Biological Society, Harvard Medical School, Boston
OPPOINTMENTS AND RESEARCH POSITIONS
2004-present Associate Scientific Staff/Instructor, Department of Urology, Children's Hospital Boston/ Department of Sergery, Harvard Medical School
2000-2004 Postdoc/Research Fellow, Department of Urology, Harvard Medical School, Children's Hospital Boston
1999-2000 Associate Scientist, Department of Ophthalmology, Yonsei University, Seoul, Korea
1998-1999 Research Associate, East-West Medical Research Center, Kyung Hee University, Seoul, Korea
1998-1999 Teaching Assistant of Molecular Biology, Dept. of Molecular Biology, Kyung Hee University, Seoul, Korea
1996-1998 Research Associate, Research Center for Cell Differentiation, Seoul National University, Seoul, Korea
1995-1996 Research Associate and Teaching Assistant, Sookmyeong Women's University, Seoul, Korea
1993-1995 Research Associate and Teaching Assistant, Ulsan University, Ulsan, Korea
HONORS and AWARDS
2004 Best poster award and Travel award for the AICR/WCRF International Conference on Food, Nutrition and Cancer.
1999 Winner of the Young Scientists Academic Fund, Korean Research Foundation, Seoul, Korea. Project title: The Mechanism in the cardiomyoblasts growth and differentiation by p38MAPK and Phosphatidylinositide (PI)3-kinase.
1998 Graduate Scholarship for Academic Achievement, Kyung Hee University, Korea
1995 Winner of the Young Scientists Academic Fund, Korean Research Foundation, Seoul, Korea. Project title: Purification and characterization of PNP.
1993 Honor Student Award, Ulsan University, Korea
1989-1993 Tuition Grant Scholarship for Merit, Ulsan University, Korea
RESEARCH FUNDING-AWARDED GRANTS
2004-present : American Foundation for Urological Disease Research Scholar (AFUD), USA
PROFESSIONAL AFFILIATIONS
2003-present : Associate member of American Association of Cancer Research (AACR), USA
2000-present : Member of New England Biological Society, USA
LEADERSHIP ROLES
2005- : President-Elect of New Englad BioScience Society (NEBS), USA
2003-2004 : President of Weekly Journal Club in Harvard Medical School, USA
관련사이트 및 보도자료
- The Freeman Lab. http://www.freemanlab.org/news/mar19.htm
- High Cholesterol feeds prostate cancer: High cholesterol levels accelerate the growth of prostate tumors, research has found. BBC News, Friday, 18 March, 2005.
- High cholesterol levels accelerate growth of prostate cancer, Medical News Today 18 Mar 2005.
- High Cholesterol May Speed Prostate Cancer: Lowering Cholesterol Levels May Slow Growth of Prostate Cancer Tumors. Web MD Health, March 18, 2005.
- High Cholesterol Drives Prostate Cancer ABC News, March 19, 2005.