경희대학교 의과대학·의학전문대학원

1. Research focus:
- (1) To develop influenza universal vaccines which are effective in eliciting protective immune responses against influenza viral infection, especially pandemic influenza. The research is focused on combination of influenza virus-like particle (VLP) and adjuvant based vaccines, with specific emphasis on inducing broadly reactive cross protection.
- (2) To develop Clinorchis sinensis, Trichinella spiralis, malaria vaccines which are effective in eliciting protective immune response against live parasite infections. The vaccine type is virus-like particles (VLPs). To find safe and effective adjuvants are also research focus.
2. 국제 특허 (Patent): Virus-like carriers, RSV, Compositions, And Method Related Thereto
3. 국내 특허: 아디프 산을 유효성분으로 포함하는 폐렴 간균에 대한 항균용 조성물
4. 연구비 실적
- (1) 09/01/2009 ? 08/31/2011, 미국 NIH 1R43AI081385 (PI, 연구책자),
Adjuvant-containing chimeric virus-like particles as improved influenza vaccines
- (2) 07/01/2010 ? 06/30/2012, 미국 NIH 1R43AI091230 (PI, 연구책임자),
Virus-like particle vaccines against respiratory syncytial virus
- (3)03/01/2012 - 12/30/2013, 농촌진흥청 PJ006893 (PI, 연구책임자),
동애등에 유래 신소재 항균물질 개발
- (4) 05/01/2014 - 04/30/2017, 한국연구재단 NRF-2014R1A2A2A01004899 (PI, 연구책임자),
바이러스 유사 입자를 이용하여 호흡기 세포융합 바이러스 백신 개발을 위한 근간 연구
- (5) 08/14/2015 - 08/15/2018, 농업기술과학평가원 315030-03-1-HD020 (PI, 연구책임자),
면역유도 동애등에로부터 천연방부제 대량정제 기술 개발

- 조교수: 국립충주대학교 보건대학 생명공학과 (2011. 09.01 ? 2012.02.28)
- 전임강사: Emory University School of Medicine, Dept. Microbiology & Immunology, Atlanta, GA USA
(2007.10.01 ? 2011.08.31)
- 박사 후: Emory University School of Medicine, Dept. Microbiology & Immunology, Atlanta, GA USA
(2003.12.01 ? 2007.09.30)
- 박사: 고려대학교 의과대학, 서울 암암캠퍼스 (1999.02.25)
- 의사자격: Licensures/Boards: Medical license

- American Society for Virology,
- Korean Society for Parasitology

Publications in SCI Journals since 2010
Year 2010
1. Kim Y. C., Quan F.S., Compans R. W., Kang S. M., Prausnitz M (2010). Enhanced memory responses to H1N1 influenza vaccination in the skin using vaccine coated-microneedles. Journal of Infectious Diseases. Jan 15; 201(2):190-8
2. Quan F. S., Vunnava A., Compans R.W, Kang S.M. (2010). Virus-like particle vaccine protects against 2009 H1N1 pandemic influenza virus. PLoS One. Feb 11; 5(2):e9161
3. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR. Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity. J Control Release. 2010 Mar 3; 142(2):187-95
4. Kim YC, Quan FS, Song JM, Vunnava A, Yoo DG, Park KM, Compans RW, Kang SM, Prausnitz MR. Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles, Procedia Vaccinol. 2010; 2(1):15-19.
5. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR. Stability kinetics of influenza vaccine coated onto microneedles during drying and storage. Pharm Res. 2010 Jan; 28(1):135-44. Epub 2010 Apr 13.
6. Quan FS, Kim YC, Vunnava A, Yoo DG, Song JM, Prausnitz MR, Compans RW, Kang SM. Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization. J Virol. 2010 Aug; 84(15):7760-9.
7. Song JM, Hossain J, Yoo DG, Lipatov AS, Davis CT, Quan FS, Chen LM, Hogan RJ, Donis RO, Compans RW, Kang SM. Protective immunity against H5N1 influenza virus by a single dose vaccination with virus-like particles, Virology. 2010 Sep 15; 405(1):165-75.
8. Song JM, Kim YC, Lipatov AS, Pearton M, Davis CT, Yoo DG, Park KM, Chen LM, Quan FS, Birchall JC, Donis RO, Prausnitz MR, Compans RW, Kang SM. Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice, Clin Vaccine Immunol. 2010 Sep;17(9):1381-9
9. Kim YC, Quan FS, Compans RW, Kang SM, Prausnitz MR. Formulation of microneedles coated with influenza virus-like particle vaccine, AAPS PharmSciTech. 2010, Sep; 11(3):1193-201
10. Pearton M, Kang SM, Song JM, Kim YC, Quan FS, Anstey A, Ivory M, Prausnitz MR, Compans RW, Birchall JC. Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin, Vaccine. 2010 Aug 23;28(37):6104-13
11. Quan FS, Kim YC, Compans RW, Prausnitz MR, Kang SM. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles, J Control Release. 2010 Nov 1; 147(3):326-32.
12. Wang BZ, Xu R, Quan FS, Kang SM, Wang L, Compans RW. Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection, PLoS One. 2010 Nov 29; 5(11)
Year 2011
13. Song JM, Wang BZ, Park KM, Van Rooijen N, Quan FS, Kim MC, Jin HT, Pekosz A, Compans RW, Kang SM. Influenza virus-like particles containing M2 induce broadly cross protective immunity, PLoS One. 2011 Jan 18; 6(1):e14538
14. Quan FS, Li ZN, Kim MC, Yang D, Compans RW, Steinhauer DA, Kang SM. Immunogenicity of low-pH treated whole viral influenza vaccine, Virology. 2011 Aug 15; 417(1):196-202
15. Kang SM, Yoo DG, Kim MC, Song JM, Park MK, O E, Quan FS, Akira S, Compans RW. MyD88 plays an essential role in inducing B cells capable of differentiating into antibody-secreting cells after vaccination, J Virol. 2011 Nov; 85(21):11391-400
16. Quan FS, Kim Y, Lee S, Yi H, Kang SM, Bozja J, Moore ML, Compans RW. Viruslike particle vaccine induces protection against respiratory syncytial virus infection in mice, J Infect Dis. 2011 Oct 1; 204(7):987-95
17. Hossain MJ, Bourgeois M, Quan FS, Lipatov AS, Song JM, Chen LM, Compans RW, York I, Kang SM, Donis RO. Virus-like particle vaccine containing hemagglutinin confers protection against 2009 H1N1 pandemic influenza. Clin Vaccine Immunol. 2011 Dec; 18(12):2010-7
Year 2012
18. Quan FS, Compans RW, Kang SM. Oral vaccination with inactivated influenza vaccine induces cross-protective immunity, Vaccine. 2012 Jan 5; 30(2):180-8.
19. Choi HJ, Yoo DG, Bondy BJ, Quan FS, Compans RW, Kang SM, Prausnitz MR.,Stability of influenza vaccine coated onto microneedles. Biomaterials. 2012 May;33(14):3756-69.
20. Yoo DG, Kim MC, Park MK, Park KM, Quan FS, Song JM, Wee JJ, Wang BZ, Cho YK, Compans RW, Kang SM. Protective effect of ginseng polysaccharides on influenza viral infection, PLoS One. 2012;7(3):e33678. Epub 2012 Mar 19.
21. Quan FS, Kim MC, Lee BJ, Song JM, Compans RW, Kang SM., Influenza M1 VLPs containing neuraminidase induce heterosubtypic cross-protection, Virology. 2012 Sep 1;430(2):127-35.
22. Shastri PN, Kim MC, Quan FS, D'Souza MJ, Kang SM., Immunogenicity and protection of oral influenza vaccines formulated into microparticles., J Pharm Sci. 2012 Oct;101(10):3623-35
23. Yoo DG, Kim MC, Park MK, Song JM, Quan FS, Park KM, Cho YK, Kang SM., Protective Effect of Korean Red Ginseng Extract on the Infections by H1N1 and H3N2 Influenza Viruses in Mice, J Med Food. 2012 Aug 2.
Year 2013
24. Quan FS, Ko EJ, Kwon YM, Joo KH, Compans RW, Kang SM. Mucosal adjuvants for influenza virus-like particle vaccine. Viral Immunol. 2013 Dec;26(6):385-95. doi: 10.1089/vim.2013.0013. Epub 2013 Nov 16.
25. Kang SW, Kim OK, Seo B, Lee SH, Quan FS, Shin JH, Lee GJ, Park HK. Simultaneous, real-time measurement of nitric oxide and oxygen dynamics during cardiac ischemia-reperfusion of the rat utilizing sol-gel-derived electrochemical microsensors. Anal Chim Acta. 2013 Nov 13;802:74-81. doi: 10.1016/j.aca.2013.09.029. Epub 2013 Sep 25.
26. Quan FS, Kim YC, Song JM, Hwang HS, Compans RW, Prausnitz MR, Kang SM. Long-term protective immunity from an influenza virus-like particle vaccine administered with a microneedle patch. Clin Vaccine Immunol. 2013 Sep;20(9):1433-9. doi: 10.1128/CVI.00251-13. Epub 2013 Jul 17.
27. Choi HJ, Ebersbacher CF, Quan FS, Montemagno CD. pH stability and comparative evaluation of ranaspumin-2 foam for application in biochemical reactors. Nanotechnology. 2013 Feb 8;24(5):055603. doi: 10.1088/0957-4484/24/5/055603. Epub 2013 Jan 16.
Year 2014
28. Lee JH, Li DX, Yoon H, Go D, Quan FS, Min BI, Kim SK. BMC Complement Altern Med. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471.
29. Lee S, Quan FS, Kwon Y, Sakamoto K, Kang SM, Compans RW, Moore ML. Additive protection induced by mixed virus-like particles presenting respiratory syncytial virus fusion or attachment glycoproteins. Antiviral Res. 2014 Nov;111:129-35. doi: 10.1016/j.antiviral.2014.09.005. Epub 2014 Sep 18.
30. Lee JS, Kwon YM, Hwang HS, Lee YN, Ko EJ, Yoo SE, Kim MC, Kim KH, Cho MK, Lee YT, Lee YR, Quan FS, Kang SM. Baculovirus-expressed virus-like particle vaccine in combination with DNA encoding the fusion protein confers protection against respiratory syncytial virus. Vaccine. 2014 Oct 7;32(44):5866-74. doi: 10.1016/j.vaccine.2014.08.045. Epub 2014 Aug 27.
31. Ko EJ, Kwon YM, Lee JS, Hwang HS, Yoo SE, Lee YN, Lee YT, Kim MC, Cho MK, Lee YR, Quan FS, Song JM, Lee S, Moore ML, Kang SM. Virus-like nanoparticle and DNA vaccination confers protection against respiratory syncytial virus by modulating innate and adaptive immune cells. Nanomedicine. 2015 Jan;11(1):99-108. doi: 10.1016/j.nano.2014.07.013. Epub 2014 Aug 8.
32. Kim HI, Quan FS, Kim JE, Lee NR, Kim HJ, Jo SJ, Lee CM, Jang DS, Inn KS. Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. Biochem Biophys Res Commun. 2014 Aug 22;451(2):282-7. doi: 10.1016/j.bbrc.2014.07.115. Epub 2014 Aug 1.
33. Kim SK, Sun B, Yoon H, Lee JH, Lee G, Sohn SH, Kim H, Quan FS, Shim I, Ha J, Min BI, Bae H. Expression levels of the hypothalamic AMPK gene determines the responsiveness of the rats to electroacupuncture-induced analgesia. BMC Complement Altern Med. 2014 Jun 30;14:211. doi: 10.1186/1472-6882-14-211.
34. Chu KB, Kim SS, Lee SH, Lee HS, Joo KH, Lee JH, Lee YS, Zheng S, Quan FS. Enhanced protection against Clonorchis sinensis induced by co-infection with Trichinella spiralis in rats. Parasite Immunol. 2014 Oct;36(10):522-30. doi: 10.1111/pim.12125.
35. Kim MC, Lee YN, Ko EJ, Lee JS, Kwon YM, Hwang HS, Song JM, Song BM, Lee YJ, Choi JG, Kang HM, Quan FS, Compans RW, Kang SM. Supplementation of influenza split vaccines with conserved M2 ectodomains overcomes strain specificity and provides long-term cross protection. Mol Ther. 2014 Jul;22(7):1364-74. doi: 10.1038/mt.2014.33. Epub 2014 Mar 4.
36. Gill HS, Kang SM, Quan FS, Compans RW. Cutaneous immunization: an evolving paradigm in influenza vaccines. Expert Opin Drug Deliv. 2014 Apr;11(4):615-27. doi: 10.1517/17425247.2014.885947. Epub 2014 Feb 12. Review.
37. Inn KS, Lee GJ, Quan FS. A pandemic H1N1 influenza virus-like particle vaccine induces cross-protection in mice. Immunol Invest. 2014;43(3):236-54.
38. Shin JH, Park JK, Lee DH, Quan FS, Song CS, Kim YC, 2015, Microneedle Vaccination Elicits Superior Protection and Antibody Response over Intranasal Vaccination against Swine-Origin Influenza A (H1N1) in Mice. PLoS One. 2015 Jun 18;10(6):e0130684.
39. Ko EJ, Kwon YM, Lee JS, Hwang HS, Yoo SE, Lee YN, Lee YT, Kim MC, Cho MK, Lee YR, Quan FS, Song JM, Lee S, Moore ML, Kang SM. Virus-like nanoparticle and DNA vaccination confers protection against respiratory syncytial virus by modulating innate and adaptive immune cells. 2015, Nanomedicine. 2015 Jan;11(1):99-108
40. Kim YC, Lee SH, Choi WH, Choi HJ, Goo TW, Lee JH, Quan FS. Microneedle delivery of trivalent influenza vaccine to the skin induces long-term cross-protection.
J Drug Target. 2016 Dec;24(10):943-951
41. Quan FS, Lee YT, Kim KH, Kim MC, Kang SM, Progress in developing virus-like particle influenza vaccines. Expert Rev Vaccines. 2016 Oct;15(10):1281-93.
42. Lee GJ, Lee SH, Lee YJ, Quan FS, Nanostructural characterization of Sf9 cells during virus-like particles generation. Scanning. 2016 Nov;38(6):735-742
43. Lee GJ, Quan FS. Protection induced by early stage vaccination with pandemic influenza virus-like particles. Vaccine. 2016 Jul 19;34(33):3764-72
44. Lee SH, Kim SS, Lee DH, Kim AR, Quan FS. Evaluation of protective efficacy induced by virus-like particles containing a Trichinella spiralis excretory-secretory (ES) protein in mice. Parasit Vectors. 2016 Jul 4;9(1):384.
45. Lee JH, Go D, Kim W, Lee G, Bae H, Quan FS, Kim SK. Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain. Korean J Physiol Pharmacol. 2016 Jul;20(4):407-14
46. Quan FS, Kim KS. Medical applications of the intrinsic mechanical properties of single cells. Acta Biochim Biophys Sin (Shanghai). 2016 Oct;48(10):865-871
47. Lee DH, Lee SH, Kim AR, Quan FS. Lee DH, Lee SH, Kim AR, Quan FS. Virus-Like Nanoparticle Vaccine Confers Protection against Toxoplasma gondii, PLoS One. 2016 Aug 22;11(8):e0161231.
48. Lee DH, Kim AR, Lee SH, Quan FS. Cross-protection induced by Toxoplasma gondii virus-like particle vaccine upon intraperitoneal route challenge. Acta Trop. 2016 Dec;164:77-83.
49. Chu KB, Kim SS, Lee SH, Lee DH, Kim AR, Quan FS. Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice. Korean J Parasitol. 2016 Oct;54(5):637-643
50. Koch B, Rubino I, Quan FS, Yoo B, Choi HJ. Microfabrication for Drug Delivery. Materials (Basel). 2016 Aug 1;9(8).
51. Quan FS, Rubino I, Lee SH, Koch B, Choi HJ. Universal and reusable virus deactivation system for respiratory protection. Sci Rep. 2017 Jan 4;7:39956
52. Moon EK, Park HR, Quan FS, Kong HH. Efficacy of Korean Multipurpose Contact Lens Disinfecting Solutions against Acanthamoeba castellanii. Korean J Parasitol. 2016 Dec;54(6):697-702.
53. Kim KS, Kim AR, Piao Y, Lee JH, Quan FS. A rapid, simple, and accurate plaque assay for human respiratory syncytial virus (HRSV). J Immunol Methods. 2017 Jul;446:15-20
54. Lee SH, Kim AR, Lee DH, Rubino I, Choi HJ, Quan FS. Protection induced by virus-like particles containing Toxoplasma gondii microneme protein 8 against highly virulent RH strain of Toxoplasma gondii infection. PLoS One. 2017 Apr 13;12(4):e0175644.
55. Moon EK, Kong HH, Hong Y, Lee HA, Quan FS. Identification and Characterization of Protein Arginine Methyltransferase 1 in Acanthamoeba castellanii. Korean J Parasitol. 2017 Apr;55(2):109-114
56. Moon EK, Hong Y, Lee HA, Quan FS, Kong HH. DNA Methylation of Gene Expression in Acanthamoeba castellanii Encystation. Korean J Parasitol. 2017 Apr;55(2):115-120
57. Lee SH, Lee DH, Piao Y, Moon EK, Quan FS. Influenza M1 Virus-Like Particles Consisting of Toxoplasma gondii Rhoptry Protein 4. Korean J Parasitol. 2017 Apr;55(2):143-148.
58. Moon EK, Lee SH, Goo TW, Quan FS. Immune responses induced by co-infection with Capillaria hepatica in Clonorchis sinensis-infected rats. J Helminthol. 2017 Aug 8:1-8.
59. Kim J, Yun EY, Quan FS, Park SW, Goo TW. Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity. Evid Based Complement Alternat Med. 2017;3607089
60. Choi J1, Jeon C2, Lee JH3, Jang JU4, Quan FS5, Lee K6, Kim W7,8, Kim SK9,10,11,
Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats: Mediation by Spinal α₂-Adrenergic Receptor, Toxins (Basel). 2017 Oct 31;9(11). pii: E351
61. Kim MJ, Lee JH, Jang JU, Quan FS, Kim SK, Kim W. The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain. Korean J Physiol Pharmacol. 2017 Nov;21(6):657-666.
62. Gangadhara S, Kwon YM, Jeeva S, Quan FS, Wang B, Moss B, Compans RW, Amara RR, Jabbar MA, Kang SM. Vaccination with Combination DNA and Virus-Like Particles Enhances Humoral and Cellular Immune Responses upon Boost with Recombinant Modified Vaccinia Virus Ankara Expressing Human Immunodeficiency Virus Envelope Proteins. Vaccines (Basel). 2017 Dec 19;5(4).
63. Lee DH, Kim AR, Lee SH, Quan FS. Virus-like particles vaccine containing Clonorchis sinensis tegumental protein induces partial protection against Clonorchis sinensis infection. Parasit Vectors. 2017 Dec 29;10(1):626
64. Kim AR, Lee DH, Lee SH, Rubino I, Choi HJ, Quan FS. Protection induced by virus-like particle vaccine containing tandem repeat gene of respiratory syncytial virus G protein. PLoS One. 2018 Jan 16;13(1):e0191277
65. Moon EK, Lee S, Quan FS, Kong HH. Chloroquine as a possible disinfection adjunct of disinfection solutions against Acanthamoeba. Exp Parasitol. 2018 May;188:102-106.
66. Moon EK, Lee SH, Soh Y, Guo YR, Piao Y, Quan FS. Correlates of Immune Response in Trichinella spiralis Infection. Immunol Invest. 2018 Aug;47(6):605-614.
67. Quan FS, Jeong KH, Lee GJ. Ultrastructural and mechanical changes in tubular epithelial cells by angiotensin II and aldosterone as observed with atomic force microscopy. Micron. 2018 Jul;110:50-56
68. Moon EK, Choi HS, Kong HH, Quan FS. Polyhexamethylene biguanide and chloroquine induce programmed cell death in Acanthamoeba castellanii. Exp Parasitol. 2018 Aug;191:31-35
69. Ahmed MA, Lau YL, Quan FS. Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia. Malar J. 2018 Jul 27;17(1):274.
70. Lee SH, Kang HJ, Lee DH, Kang SM, Quan FS. Virus-like particle vaccines expressing Toxoplasma gondii rhoptry protein 18 and microneme protein 8 provide enhanced protection. Vaccine. 2018 Sep 11;36(38):5692-5700
71. Kim KH, Kwon YM, Lee YT, Hwang HS, Kim MC, Ko EJ, Wang BZ, Quan FS, Kang SM. Virus-like particles presenting flagellin exhibit unique adjuvant effects on eliciting T helper type 1 humoral and cellular immune responses to poor immunogenic influenza virus M2e protein vaccine. Virology. 2018 Nov;524:172-181
72. Wang Y, Jung YJ, Kim KH, Kwon Y, Kim YJ, Zhang Z, Kang HS, Wang BZ, Quan FS, Kang SM. Antiviral Activity of Fermented Ginseng Extracts against a Broad Range of Influenza Viruses. Viruses. 2018 Sep 1;10(9).
73. Chu KB, Lee DH, Kang HJ, Quan FS. The resistance against Trichinella spiralis infection induced by primary infection with respiratory syncytial virus. Parasitology. 2018 Nov 5:1-9.
74. Kang HJ, Lee SH, Chu KB, Lee DH, Quan FS. Virus-Like Particles Expressing Toxoplasma gondii Rhoptry Protein 18 Induces Better Protection Than Rhoptry Protein 4 against T. gondii Infection. Korean J Parasitol. 2018 Oct;56(5):429-435
75. Moon EK, Lee S, Quan FS, Kong HH. Effect of 2, 6-Dichlorobenzonitrile on Amoebicidal Activity of Multipurpose Contact Lens Disinfecting Solutions. Korean J Parasitol. 2018 Oct;56(5):491-494
76. Moon EK, Kang HJ, Chu KB, Lee SH, Lee DH, Soh Y, Quan FS. Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins. Immunol Invest. 2018 Nov 15:1-12
77. Ahmed MA, Chu KB, Vythilingam I, Quan FS. Within-population genetic diversity and population structure of Plasmodium knowlesi merozoite surface protein 1 gene from geographically distinct regions of Malaysia and Thailand.
78. Lee HA, Lee E, Do GY, Moon EK, Quan FS, Kim I. Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death. Biomed Pharmacother. 2019 Jan;109:921-929.
79. Ban J, Lee NR, Lee NJ, Lee JK, Quan FS, Inn KS. Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling. Viruses. 2018 Dec 14;10(12).
80. Ahmed MA, Chu KB, Quan FS. The Plasmodium knowlesi Pk41 surface protein diversity, natural selection, sub population and geographical clustering: a 6-cysteine protein family member. PeerJ. 2018 Dec 14;6:e6141
81. Moon EK, Choi HS, Park SM, Kong HH, Quan FS. Comparison of Proteins Secreted into Extracellular Space of Pathogenic and Non-pathogenic Acanthamoeba castellanii. Korean J Parasitol. 2018 Dec;56(6):553-558.
82. Lee SH, Kang HJ, Lee DH, Quan FS. Protective Immunity Induced by Incorporating Multiple Antigenic Proteins of Toxoplasma gondii Into Influenza Virus-Like Particles. Front Immunol. 2019 Jan 7;9:3073.
83. Lee GJ, Chu KB, Inn KS, Moon EK, Quan FS. Vaccine Efficacy Induced by 2009 Pandemic H1N1 Virus-Like Particles Differs from that Induced by Split Influenza Virus.
Immunol Invest. 2019 Nov 27:1-13. doi: 10.1080/08820139.2019.1694539
84. Lee DH, Chu KB, Kang HJ, Lee SH, Chopra M, Choi HJ, Moon EK, Inn KS, Quan FS. Protection induced by malaria virus-like particles containing codon-optimized AMA-1 of Plasmodium berghei. Malar J. 2019 Dec 3;18(1):394. doi: 10.1186/s12936-019-3017-2.
85. Ahmed MA, Saif A, Quan FS. Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia. PLoS One. 2019 Nov 21;14(11):e0224743. doi: 10.1371/journal.pone.0224743. eCollection 2019.
86. Kang HJ, Chu KB, Lee SH, Kim MJ, Park H, Jin H, Quan FS. Virus-like Particle Vaccine Containing Toxoplasma gondii Rhoptry Protein 13 Induces Protection against T. gondii ME49 Infection in Mice. Korean J Parasitol. 2019 Oct;57(5):543-547
87. Lee SH, Chu KB, Quan FS.Parasite Infiltration and Apoptosis in Spleen upon Toxoplasma gondii Infection. Korean J Parasitol. 2019 Oct;57(5):537-541
88. Atique Ahmed M, Kang HJ, Quan FS. Low Levels of Polymorphisms and Negative Selection in Plasmodum knowlesi Merozoite Surface Protein 8 in Malaysian Isolates. Korean J Parasitol. 2019 Aug;57(4):445-450.
89. Lee SH, Chu KB, Kang HJ, Quan FS. Virus-like particles containing multiple antigenic proteins of Toxoplasma gondii induce memory T cell and B cell responses.
PLoS One. 2019 Aug 29;14(8):e0220865
90. Chu KB, Lee HA, Moon EK, Quan FS.Resistance against Trichinella spiralis infection in pups delivered by T. spiralis-infected dam. Vet Parasitol. 2019 Sep;273:60-66.
91. Kang HJ, Lee SH, Kim MJ, Chu KB, Lee DH, Chopra M, Choi HJ, Park H, Jin H, Quan FS. Influenza Virus-Like Particles Presenting both Toxoplasma gondii ROP4 and ROP13 Enhance Protection against T. gondii Infection. Pharmaceutics. 2019 Jul 16;11(7):342. doi: 10.3390/pharmaceutics11070342.
92. Kwon YM, Hwang HS, Lee YT, Kim KH, Lee Y, Kim MC, Lee YN, Quan FS, Moore ML, Kang SM. Respiratory Syncytial Virus Fusion Protein-encoding DNA Vaccine Is Less Effective in Conferring Protection against Inflammatory Disease than a Virus-like Particle Platform. Immune Netw. 2019 May 27;19(3):e18
93. Kang HJ, Chu KB, Lee DH, Lee SH, Park BR, Kim MC, Kang SM, Quan FS. Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs. PLoS One. 2019 Jun 27;14(6):e0216871
94. Lee DH, Chu KB, Kang HJ, Lee SH, Quan FS. Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice. Korean J Parasitol. 2019 Apr;57(2):93-99.
95. Ahmed MA, Quan FS. Plasmodium knowlesi clinical isolates from Malaysia show extensive diversity and strong differential selection pressure at the merozoite surface protein 7D (MSP7D). Malar J. 2019 Apr 29;18(1):150.
96. Genetic diversity of zoonotic malaria parasites from mosquito vector and vertebrate hosts. Wong ML, Ahmed MA, Sulaiman WYW, Manin BO, Leong CS, Quan FS, Chua TH, Drakeley C, Snounou G, Vythilingam I. Infect Genet Evol. 2019 Sep;73:26-32.
97. Kwon S, Lee DH, Han SJ, Yang W, Quan FS, Kim KS. Biomechanical properties of red blood cells infected by Plasmodium berghei ANKA. J Cell Physiol. 2019 Nov;234(11):20546-20553
98. Quan FS, Lee HA, Kong HH, Moon EK. Histone Deacetylase Inhibitors Enhance the Amoebicidal Effect of Low Concentration of Polyhexamethylene Biguanide by Inducing Apoptosis. Cornea. 2020 Feb;39(2):245-249
99. Lee HA, Chu KB, Moon EK, Kim SS, Quan FS. Sensitization to oxidative stress and G2/M cell cycle arrest by histone deacetylase inhibition in hepatocellular carcinoma cells. Free Radic Biol Med. 2020 Feb 1;147:129-138.
100. Quan FS, Basak S, Chu KB, Kim SS, Kang SM. Progress in the development of virus-like particle vaccines against respiratory viruses. Expert Rev Vaccines. 2020 Jan;19(1):11-24.
111. Lee HA, Moon EK, Quan FS. Combination of tert-butyl hydroperoxide with vorinostat induces cell death of Acanthamoeba through cell cycle arrest. Exp Parasitol. 2020 Mar;210:107833.
112. Kim MJ, Lee SH, Kang HJ, Chu KB, Park H, Jin H, Moon EK, Kim SS, Quan FS. Virus-like particle vaccine displaying Toxoplasma gondii apical membrane antigen 1 induces protection against T. gondii ME49 infection in mice. Microb Pathog. 2020 Feb 22;142:104090.
113. Kang HJ, Chu KB, Lee SH, Kim MJ, Park H, Jin H, Moon EK, Quan FS. Toxoplasma gondii virus-like particle vaccination alleviates inflammatory response in the brain upon T gondii infection. Parasite Immunol. 2020 Jun;42(6):e12716.
114. Basak S, Kang HJ, Lee SH, Chu KB, Moon EK, Quan FS.Influenza vaccine efficacy induced by orally administered recombinant baculoviruses. PLoS One. 2020 May 27;15(5):e0233520.
115. Chu KB, Lee HA, Kang HJ, Moon EK, Quan FS. Preliminary Trichinella spiralis Infection Ameliorates Subsequent RSV Infection-Induced Inflammatory Response. Cells. 2020 May 25;9(5):1314
116. Lee SH, Chu KB, Kang HJ, Basak S, Kim MJ, Park H, Jin H, Moon EK, Quan FS. Virus-like particles expressing Plasmodium berghei MSP-8 induce protection against P. berghei infection. Parasite Immunol. 2020 Jun;42(6):e12716. doi: 10.1111/pim.12716. Epub 2020 Apr 20.
117. Lee SH, Kang HJ, Chu KB, Basak S, Lee DH, Moon EK, Quan FS. Protective Immunity Induced by Virus-Like Particle Containing Merozoite Surface Protein 9 of Plasmodium berghei. Vaccines (Basel). 2020 Jul 30;8(3):E428. doi: 10.3390/vaccines8030428.
118. Rubino I, Oh E, Han S, Kaleem S, Hornig A, Lee SH, Kang HJ, Lee DH, Chu KB, Kumaran S, Armstrong S, Lalani R, Choudhry S, Kim CI, Quan FS, Jeon B, Choi HJ. Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases, Sci Rep. 2020 Aug 17;10(1):13875. doi: 10.1038/s41598-020-70623-9.
119. Swarnendu Basaka, Ki-BackChu, Hae-Ji Kang, Min-Ju Kim, Su-Hwa Lee, Keon-Woong Yoon, Hui Jin, Joo Won Suh, Eun-Kyung Moon, Fu-Shi Quan. Orally administered recombinant baculovirus vaccine elicits partial protection against avian influenza virus infection in mice, Mrobial Pathogenesis, Volume 149, December 2020, 104495
120. Dong-Hun Lee , Ki-Back Chua , Hae-Ji Kanga , Su-Hwa Leea , Fu-Shi Quan, Peptides in the hemolymph of Hermetia illucens larvae completely inhibit the growth of Klebsiella pneumonia in vitro and in vivo, Journal of Asia-Pacific Entomology, Volume 23, Issue 1, April 2020, Pages 36-43
121. Lee HA, Park SM, Chu KB, Quan FS, Kurz T, Pflieger M, Moon EK. Production of a polyclonal antibody against inosine-uridine preferring nucleoside hydrolase of Acanthamoeba castellanii and its access to diagnosis of Acanthamoeba keratitis. PLoS One. 2020 Sep 30;15(9):e0239867.
122. Lee HA, Park SM, Chu KB, Quan FS, Kurz T, Pflieger M, Moon EK. Application of histone deacetylase inhibitors MPK472 and KSK64 as a potential treatment option for Acanthamoeba keratitis. Antimicrob Agents Chemother, 2020 Sep 14;AAC.01506-20.
123. Kang HJ, Chu KB, Kim MJ, Lee SH, Park H, Jin H, Moon EK, Quan FS. Protective immunity induced by CpG ODN-adjuvanted virus-like particles containing Toxoplasma gondii proteins. Parasite Immunol. 2020 Oct 15:e12799.
124. Kang HJ, Chu KB, Kim MJ, Park H, Jin H, Lee SH, Moon EK, Quan FS. Evaluation of CpG-ODN-Adjuvanted Toxoplasma Gondii Virus-Like Particle Vaccine upon One, Two, and Three Immunizations. Pharmaceutics. 2020 Oct 19;12(10):989
125. Chu KB, Quan FS. Virus-Like Particle Vaccines Against Respiratory Viruses and Protozoan Parasites. Curr Top Microbiol Immunol. 2021 Mar 3. doi: 10.1007/82_2021_232. Online ahead of print. PMID: 33650036
126. Lee HA, Chu KB, Kim MJ, Quan FS, Kong HH, Moon EK. Chorismate mutase peptide antibody enables specific detection of Acanthamoeba. PLoS One. 2021 Apr 23;16(4):e0250342. doi: 10.1371/journal.pone.0250342. eCollection 2021. PMID: 33891646
127. Basak S, Kang HJ, Chu KB, Oh J, Quan FS. Simple and rapid plaque assay for recombinant baculoviruses expressing influenza hemagglutinin. Sci Prog. 2021 Jan-Mar;104(1):368504211004261. doi: 10.1177/00368504211004261.
128. Rubino I, Han S, Oh E, Kumaran S, Lawson M, Jung YJ, Kim KH, Bhatnagar N, Lee SH, Kang HJ, Lee DH, Chu KB, Kang SM, Quan FS, Choi HJ. Study of the Pathogen Inactivation Mechanism in Salt-Coated Filters. ACS Appl Mater Interfaces. 2021 Apr 14;13(14):16084-16096. doi: 10.1021/acsami.1c01837. Epub 2021 Apr 1.
129. Chu KB, Quan FS. Advances in Toxoplasma gondii Vaccines: Current Strategies and Challenges for Vaccine Development. Vaccines (Basel). 2021 Apr 21;9(5):413. doi: 10.3390/vaccines9050413. PMID: 33919060
130. Kang HJ, Kim MJ, Chu KB, Lee SH, Moon EK, Quan FS. Passive Immunity and Antibody Response Induced by Toxoplasma gondii VLP Immunization. Vaccines (Basel). 2021 Apr 23;9(5):425. doi: 10.3390/vaccines9050425.
131. Lee HA, Chu KB, Kim MJ, Quan FS, Kong HH, Moon EK; Chorismate mutase peptide antibody enables specific detection of Acanthamoeba; PLoS One. 2021 Apr 23;16(4):e0250342. doi: 10.1371/journal.pone.0250342. eCollection 2021
132. Lee HA, Chu KB, Moon EK, Quan FS; Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression, J Cancer. 2021 Jun 22;12(17):5086-5098. doi: 10.7150/jca.60027.
133. Chu KB, Kang HJ, Yoon KW, Lee HA, Moon EK, Han BK, Quan FS, Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains, Vaccines (Basel). 2021 Aug 18;9(8):920. doi: 10.3390/vaccines9080920
134. Quan FS, Lee GJ, Analytical Methods for Detection of Gasotransmitter Hydrogen Sulfide Released from Live Cells, Biomed Res Int. 2021 Aug 28;2021:5473965. doi: 10.1155/2021/5473965.
135. Lee SH, Chu KB, Kang HJ, Kim MJ, Moon EK, Quan FS, Respiratory virus deterrence induced by modified mask filter, PLoS One. 2021 Sep 30;16(9):e0257827. doi: 10.1371/journal.pone.0257827
136. Yoon KW, Chu KB, Kang HJ, Kim MJ, Eom GD, Lee SH, Moon EK, Quan FS, Mucosal Administration of Recombinant Baculovirus Displaying Toxoplasma gondii ROP4 Confers Protection Against T. gondii Challenge Infection in Mice, Front Cell Infect Microbiol. 2021 Sep 29;11:735191. doi: 10.3389/fcimb.2021.735191.
137. Lee HA, Chu KB, Moon EK, Quan FS, Glutathione Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum Stress and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells. Antioxidants (Basel). 2021 Sep 22;10(10):1503. doi: 10.3390/antiox10101503.
138. Kang HJ, Chu KB, Yoon KW, Eom GD, Mao J, Kim MJ, Lee SH, Moon EK, Quan FS. Neuraminidase in Virus-like Particles Contributes to the Protection against High Dose of Avian Influenza Virus Challenge Infection, Pathogens. 2021 Oct 7;10(10):1291. doi: 10.3390/pathogens10101291.
139. Moon EK, Kim MJ, Lee HA, Quan FS, Kong HH. Comparative analysis of differentially expressed genes in Acanthamoeba after ingestion of Legionella pneumophila and Escherichia coli, Exp Parasitol. 2022 Jan;232:108188. doi: 10.1016/j.exppara.2021.108188.
140. Kim MJ, Mao J, Kang HJ, Chu KB, Quan FS. Detection of Toxoplasma gondii Infections using Virus-Like Particles Displaying T. gondii ROP4 Antigen. Korean J Parasitol. 2021 Dec;59(6):565-572. doi: 10.3347/kjp.2021.59.6.565.
141. Kim MJ, Chu KB, Lee HA, Quan FS, Kong HH, Moon EK. Detection of Acanthamoeba spp. using carboxylesterase antibody and its usage for diagnosing Acanthamoeba-keratitis. PLoS One. 2022 Jan 5;17(1):e0262223. doi: 10.1371/journal.pone.0262223
142. Chu KB, Lee HA, Pflieger M, Fischer F, Asfaha Y, Alves Avelar LA, Skerhut A, Kassack MU, Hansen FK, Schöler A, Kurz T, Kim MJ, Moon EK, Quan FS. Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii. ACS Infect Dis. 2022 Feb 11;8(2):271-279. doi: 10.1021/acsinfecdis.1c00390. Epub 2022 Jan 7.
143. Ahmed MA, Deshmukh GY, Zaidi RH, Saif A, Alshahrani MA, Wazid SW, Patgiri SJ, Quan FS. Identification, Mapping, and Genetic Diversity of Novel Conserved Cross-Species Epitopes of RhopH2 in Plasmodium knowlesi With Plasmodium vivax, Front Cell Infect Microbiol. 2022 Jan 13;11:810398.
144. Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Min-Ju Kim, Su-Hwa Lee, Eun-Kyung Moon and Fu-Shi Quan, Multiple Neuraminidase Containing Influenza Virus-Like Particle Vaccines Protect Mice from Avian and Human Influenza Virus Infection, Viruses 2022, 14, 429. https://doi.org/10.3390/v14020429
145. Lee SH, Chu KB, Kang HJ, Quan FS. Protection and Alleviated Inflammation Induced by Virus-like Particle Vaccines Containing Plasmodium berghei MSP-8, MSP-9 and RAP1. Vaccines (Basel). 2022 Jan 27;10(2):203. doi: 10.3390/vaccines10020203.
146. Ahmed MA, Deshmukh GY, Zaidi RH, Saif A, Alshahrani MA, Wazid SW, Patgiri SJ, Quan FS. Identification, Mapping, and Genetic Diversity of Novel Conserved Cross-Species Epitopes of RhopH2 in Plasmodium knowlesi With Plasmodium vivax. Front Cell Infect Microbiol. 2022 Jan 13;11:810398.
147. Kim MJ, Lee HA, Quan FS, Kong HH, Moon EK. Characterization of a Peptide Antibody Specific to the Adenylyl Cyclase-Associated Protein of Acanthamoeba castellanii. Korean J Parasitol. 2022 Feb;60(1):7-14.