이윤성 교수
- 영문이름 -
- Yoonsung Lee
- 교실 -
- 융합의과학교실
- 전공 -
- 발생유전학
- 연락처 -
- 02-440-6290
- 연구실 -
- 강동경희대병원 서희스타힐스
- E-mail -
- ylee3699@khu.ac.kr
제브라피쉬를 이용한 중개연구: 질환 유전자 기능 규명 및 치료 전략 개발
1. 혈액질환의 병리기전 이해 및 조혈모세포 발생 기전 규명
- 조혈모세포 발생에 필수적인 새로운 유전자의 기능 및 기전 규명
- DNA 복구 관련 유전자의 조혈 발생 및 혈액질환 연관 기전 연구
- 백혈병 유발 및 진행과 관련된 유전자의 기능 분석 및 제브라피쉬 질환 모델 개발
2. 제브라피쉬 약물 스크리닝 플랫폼 개발 및 항염증 천연물 발굴
- 면역 및 염증 억제에 효과적인 천연물질의 발굴 및 작용 기전 규명
- 한방 약재의 항염증 효과 및 안전성 평가
- 고속 스캐너 시스템 기반 AI 자동화 스크리닝 플랫폼 개발
3. 임상연구팀과의 협업을 통한 제브라피쉬 기반 중개연구
- 흑색점 및 피부질환 관련 유전자의 기능 분석 및 질환 모델링
- 희귀 유전질환 관련 유전자 변이의 병리적 기능 규명
- 녹내장 유발 유전자의 기능 연구 및 모델 개발
1. 혈액질환의 병리기전 이해 및 조혈모세포 발생 기전 규명
- 조혈모세포 발생에 필수적인 새로운 유전자의 기능 및 기전 규명
- DNA 복구 관련 유전자의 조혈 발생 및 혈액질환 연관 기전 연구
- 백혈병 유발 및 진행과 관련된 유전자의 기능 분석 및 제브라피쉬 질환 모델 개발
2. 제브라피쉬 약물 스크리닝 플랫폼 개발 및 항염증 천연물 발굴
- 면역 및 염증 억제에 효과적인 천연물질의 발굴 및 작용 기전 규명
- 한방 약재의 항염증 효과 및 안전성 평가
- 고속 스캐너 시스템 기반 AI 자동화 스크리닝 플랫폼 개발
3. 임상연구팀과의 협업을 통한 제브라피쉬 기반 중개연구
- 흑색점 및 피부질환 관련 유전자의 기능 분석 및 질환 모델링
- 희귀 유전질환 관련 유전자 변이의 병리적 기능 규명
- 녹내장 유발 유전자의 기능 연구 및 모델 개발
1993-2000 B.S. Oceanography, Seoul National University, Seoul, Korea
2000-2002 B.S. Biological Sciences, Seoul National University, Seoul, Korea
2002 Research Assistant, Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
2003-2009 Ph.D. Cell Biology, Duke University, Durham, NC, USA
2009-2015 Postdoctoral fellow, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
2015-2021 Section Head & Investigator, Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea
2018-2021 Adjunct Professor, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea
2021- Associate Professor, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea
2000-2002 B.S. Biological Sciences, Seoul National University, Seoul, Korea
2002 Research Assistant, Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA
2003-2009 Ph.D. Cell Biology, Duke University, Durham, NC, USA
2009-2015 Postdoctoral fellow, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA
2015-2021 Section Head & Investigator, Center for Genomic Integrity, Institute for Basic Science, Ulsan, Korea
2018-2021 Adjunct Professor, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea
2021- Associate Professor, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea
2025- East Asia Regional Director, International Zebrafish Society
2024- Member Committee, Korean Zebrafish Society
2023- Member Committee, The Developmental Genetics Subcommittee, The Genetics Society of Korea
2022- Member, The Genetics Society of Korea
2016- Member, Korean Society for Biochemistry and Molecular Biology
2016- Member, Korean Society for Molecular and Cellular Biology
2016- Member, Zebrafish Disease Model Society
2021-2022 Treasurer/ Developmental Genetics Subcommittee/ Education Committee, The Genetics Society of Korea
2021-2022 Member Committee, The Korean Society for Integrative Biology
2019 Scholar Committee, International Association for Comparative Research on Leukemia and Related Diseases
2010-2013 Member, Society of Hematology and Stem Cells
2005-2006 Member, Society of Developmental Biology
2024- Member Committee, Korean Zebrafish Society
2023- Member Committee, The Developmental Genetics Subcommittee, The Genetics Society of Korea
2022- Member, The Genetics Society of Korea
2016- Member, Korean Society for Biochemistry and Molecular Biology
2016- Member, Korean Society for Molecular and Cellular Biology
2016- Member, Zebrafish Disease Model Society
2021-2022 Treasurer/ Developmental Genetics Subcommittee/ Education Committee, The Genetics Society of Korea
2021-2022 Member Committee, The Korean Society for Integrative Biology
2019 Scholar Committee, International Association for Comparative Research on Leukemia and Related Diseases
2010-2013 Member, Society of Hematology and Stem Cells
2005-2006 Member, Society of Developmental Biology
Oh, C.-K., Kim, M.S., Shin, U., Kang, J.W., Kim, Y.H., Ko, H.S., Ra, J.S., Ahn, S., Choi, E.Y., Yu, S., Nam, U., Choi, T., Myung, K. and Lee, Y. (2025). SMC2 and condensin II subunits are essential for the development of hematopoietic stem and progenitor cells in zebrafish. J Cell Physiol 240: e70023.https://doi.org/10.1002/jcp.70023
ﾠ
Song, H., Shin, U., Nam, U., Lee, Y. (2024). Exploring hematopoiesis in zebrafish using forward genetic screening. Exp Mol Med 10.1038/s12276-023-01138-2
ﾠ
Park, J.W., Choi, T.I., Kim, T.Y., Lee, Y.R., Don, D.W., George-Abraham, J.K., Robak, L.A., Trandafir, C.C., Liu, P., Rosenfeld, J.A., Kim, T.H., Petit, F., Kim, Y., Cheon, C.K., Lee, Y.*, Kim, C.H. (2024). RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model. J Genet Genomics 51, 1389-1403. 10.1016/j.jgg.2024.09.016. (*Co-correspondence).
ﾠ
Lee, S.,ﾠYun, S.,Yang, H.,ﾠLee, N.,Kim, Y., Lee, S., Zamora, N.A.,ﾠMontero, S.S.,ﾠYi, D.,ﾠKim, S., Choi, S., Choi, T., Kim, M.S., Lee, Y.*, Park, Y.H. (2024). Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity. J Ethnopharmacol 10.1016/j.hep.2024.117711. (*Co-correspondence).
ﾠ
Lee, S., Ye, Q., Yang, H., Lee, S., Kim, Y., Lee, N., Gonzalez-Cox, D., Yi, D.K., Kim, S.Y., Choi, S., Choi, T., Kim, M.S., Hong, S.S., Choi, C.W., Lee, Y.*, Park, Y.H. (2024). Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3. Sci Rep 14, 5237. 10.1038/s41598-024-55651-z. (*Co-correspondence).
ﾠ
Shin, U., Choi, Y., Ko, H.S., Myung, K., Lee, S., Cheon, C.K., and Lee, Y. (2023). A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Hum Genomics 17, 44. 10.1186/s40246-023-00491-7.
ﾠ
Park, K., Yoo, H.S., Oh, C.K., Lee, J.R., Chung, H.J., Kim, H.N., Kim, S.H., Kee, K.M., Kim, T.Y., Kim, M., Kim, B.G., Ra, J.S., Myung, K., Kim, H., Han, S.H., Seo, M.D., Lee, Y.*, Kim, D.W. (2022). Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. Cancer Med 10.1002/cam4.4727. (*Co-correspondence).
ﾠ
Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y. J., Kim, Y. J., Burgess, S., Kang, S., Sood, R., Lee, Y.*, Myung, K. (2021). Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA Repair (Amst) 107, 103173. (*Co-correspondence).
ﾠ
Choe, C.P.#, Choi, S.Y.#, Kee, Y.#, Kim, M.J.#, Kim, S.H.#, Lee, Y.#, Park, H.C.#, Ro, H.# (2021). Transgenic fluorescent zebrafish lines that have revolutionized biomedical research. Lab Anim Res 37, 26. (#These authors contributed equally).
ﾠ
Espanola, S.G., Song, H., Ryu, E., Saxena, A., Kim, E., Manegold, J.E., Nasamran, C.A., Sahoo, D., Oh, C.K., Bickers, C., Shin, U., Grainger, S., Park, Y.H., Pandolfo, L., Kang, M., Kang, S., Myung, K., Cooper, K.L., Yelon, D., Traver, D., Lee, Y. (2020). Haematopoietic Stem Cell-Dependent Notch Transcription is Mediated by p53 through the Histone Chaperone Supt16h. Nat Cell Biol 22, 1411-1422.
ﾠ
Han, S.H.#, Kim, S.H.#, Kim, H.J.#, Lee, Y.#, Choi, S.Y., Park, G., Kim, D.H., Lee, A., Kim, J., Choi, J.M., Kim, Y., Myung, K., Kim, H., Kim, D.W. (2017). Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia. Leukemia 31, 1532-1539. (#These authors contributed equally).
ﾠ
Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014). FGF signaling specifies hematopoietic stem cells through its regulation of somitic Notch signaling. Nat Commun 5, 5583.
ﾠ
Pouget, C., Peterkin, T., Simoes, F., Lee, Y., Traver, D., Patient, R. (2014). FGF restricts BMP signaling and thereby the hematopoietic stem cell program in the dorsal aorta. Nat Commun 5, 5588.
ﾠ
Shin, D., Lee, Y., Poss, K.D., Stainier, D.Y.R. (2011). Restriction of hepatic competence by Fgf signaling. Development 138, 1339-1348.
ﾠ
Gonzalez-Quevedo, R., Lee, Y., Poss, K.D., Wilkinson, D.G. (2010). Neuronal regulation of the spatial patterning of neurogenesis. Dev Cell 18, 136-147.
ﾠ
Lee, Y., Nachtrab, G., Klinsawat, P.W., Hami, D., Poss, K.D. (2010). Ras controls melanocyte expansion during zebrafish fin stripe regeneration. Dis Model Mech 3, 496-503.
ﾠ
Lee, Y., Hami, D., De Val, S., Kagermeier-Schenk, B., Wills, A.A., Black, B.L., Weidinger, G., and Poss, K.D. (2009). Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol 331, 270-280.
ﾠ
Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., and Poss, K.D. (2005). Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Development 132, 5173-5183.
ﾠ
Song, H., Shin, U., Nam, U., Lee, Y. (2024). Exploring hematopoiesis in zebrafish using forward genetic screening. Exp Mol Med 10.1038/s12276-023-01138-2
ﾠ
Park, J.W., Choi, T.I., Kim, T.Y., Lee, Y.R., Don, D.W., George-Abraham, J.K., Robak, L.A., Trandafir, C.C., Liu, P., Rosenfeld, J.A., Kim, T.H., Petit, F., Kim, Y., Cheon, C.K., Lee, Y.*, Kim, C.H. (2024). RFC2 may contribute to the pathogenicity of Williams syndrome revealed in a zebrafish model. J Genet Genomics 51, 1389-1403. 10.1016/j.jgg.2024.09.016. (*Co-correspondence).
ﾠ
Lee, S.,ﾠYun, S.,Yang, H.,ﾠLee, N.,Kim, Y., Lee, S., Zamora, N.A.,ﾠMontero, S.S.,ﾠYi, D.,ﾠKim, S., Choi, S., Choi, T., Kim, M.S., Lee, Y.*, Park, Y.H. (2024). Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity. J Ethnopharmacol 10.1016/j.hep.2024.117711. (*Co-correspondence).
ﾠ
Lee, S., Ye, Q., Yang, H., Lee, S., Kim, Y., Lee, N., Gonzalez-Cox, D., Yi, D.K., Kim, S.Y., Choi, S., Choi, T., Kim, M.S., Hong, S.S., Choi, C.W., Lee, Y.*, Park, Y.H. (2024). Aiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3. Sci Rep 14, 5237. 10.1038/s41598-024-55651-z. (*Co-correspondence).
ﾠ
Shin, U., Choi, Y., Ko, H.S., Myung, K., Lee, S., Cheon, C.K., and Lee, Y. (2023). A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Hum Genomics 17, 44. 10.1186/s40246-023-00491-7.
ﾠ
Park, K., Yoo, H.S., Oh, C.K., Lee, J.R., Chung, H.J., Kim, H.N., Kim, S.H., Kee, K.M., Kim, T.Y., Kim, M., Kim, B.G., Ra, J.S., Myung, K., Kim, H., Han, S.H., Seo, M.D., Lee, Y.*, Kim, D.W. (2022). Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia. Cancer Med 10.1002/cam4.4727. (*Co-correspondence).
ﾠ
Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y. J., Kim, Y. J., Burgess, S., Kang, S., Sood, R., Lee, Y.*, Myung, K. (2021). Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA Repair (Amst) 107, 103173. (*Co-correspondence).
ﾠ
Choe, C.P.#, Choi, S.Y.#, Kee, Y.#, Kim, M.J.#, Kim, S.H.#, Lee, Y.#, Park, H.C.#, Ro, H.# (2021). Transgenic fluorescent zebrafish lines that have revolutionized biomedical research. Lab Anim Res 37, 26. (#These authors contributed equally).
ﾠ
Espanola, S.G., Song, H., Ryu, E., Saxena, A., Kim, E., Manegold, J.E., Nasamran, C.A., Sahoo, D., Oh, C.K., Bickers, C., Shin, U., Grainger, S., Park, Y.H., Pandolfo, L., Kang, M., Kang, S., Myung, K., Cooper, K.L., Yelon, D., Traver, D., Lee, Y. (2020). Haematopoietic Stem Cell-Dependent Notch Transcription is Mediated by p53 through the Histone Chaperone Supt16h. Nat Cell Biol 22, 1411-1422.
ﾠ
Han, S.H.#, Kim, S.H.#, Kim, H.J.#, Lee, Y.#, Choi, S.Y., Park, G., Kim, D.H., Lee, A., Kim, J., Choi, J.M., Kim, Y., Myung, K., Kim, H., Kim, D.W. (2017). Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia. Leukemia 31, 1532-1539. (#These authors contributed equally).
ﾠ
Lee, Y., Manegold, J.E., Kim, A.D., Pouget, C., Stachura, D.L., Clements, W.K., Traver, D. (2014). FGF signaling specifies hematopoietic stem cells through its regulation of somitic Notch signaling. Nat Commun 5, 5583.
ﾠ
Pouget, C., Peterkin, T., Simoes, F., Lee, Y., Traver, D., Patient, R. (2014). FGF restricts BMP signaling and thereby the hematopoietic stem cell program in the dorsal aorta. Nat Commun 5, 5588.
ﾠ
Shin, D., Lee, Y., Poss, K.D., Stainier, D.Y.R. (2011). Restriction of hepatic competence by Fgf signaling. Development 138, 1339-1348.
ﾠ
Gonzalez-Quevedo, R., Lee, Y., Poss, K.D., Wilkinson, D.G. (2010). Neuronal regulation of the spatial patterning of neurogenesis. Dev Cell 18, 136-147.
ﾠ
Lee, Y., Nachtrab, G., Klinsawat, P.W., Hami, D., Poss, K.D. (2010). Ras controls melanocyte expansion during zebrafish fin stripe regeneration. Dis Model Mech 3, 496-503.
ﾠ
Lee, Y., Hami, D., De Val, S., Kagermeier-Schenk, B., Wills, A.A., Black, B.L., Weidinger, G., and Poss, K.D. (2009). Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol 331, 270-280.
ﾠ
Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., and Poss, K.D. (2005). Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Development 132, 5173-5183.