경희대학교 의과대학·의학전문대학원

- 1) Ghrelin 및 GLP-1의 신경보호효과 규명 및 기전 연구
- 2) Neuroendocrine regulation of growth hormone-axis
- 3) 대사 이상이 활성산소 기능에 미치는 영향

- 1981 - 1987 경희대학교 의과대학
- 1987 - 1989 경희대학교 대학원 (석사)
- 1989 - 1992 경희대학교 대학원 (박사)
- 1990 - 1992 경희대학교 의과대학 전임강사
- 1995 - 1999 경희대학교 의과대학 조교수
- 1999 경희대학교 의과대학 부교수
- 현재 경희대학교 의과대학 교수
- 1999 - 2001 University of Illinois at Chicago, Chicago, IL

- 대한약리학회 (평위원)
- 미국내분비학회 정회원(The Endocrine Society)
- 대한 내분비학회 회원
- 한국 분자생물학회 회원

- 36. Li E, Chung H, Kim Y, Kim DH, Ryu JH, Sato H, Kojima M, Park S. Ghrelin directly stimulates adult hippocampal neurogenesis: implications for learning and memory. Endocrine Journal 2013, in press (PMID: 23411585)
- 35. Lee S, Kim Y, Li E, Park S. Ghrelin Protects Spinal Cord Motoneurons Against Chronic Glutamate Excitotoxicity by Inhibiting Microglial Activation. Korean Journal of Physiology and Pharmacology. 2012, 16: 43-48
- 34. Kim Y, Li E, Park S. Insulin-Like Growth Factor-1 Inhibits 6-Hydroxydopamine-Mediated Endoplasmic Reticulum Stress-Induced Apoptosis via Regulation of Heme Oxygenase-1 and Nrf2 Expression in PC12 Cells. International Journal of Neuroscience. 2012, 122: 641-649
- 33. Park S. Changes in Growth Hormone-Axis Function in Nutrient Excess or Deprivation. Endocrinology and Metabolism. 2011, 26: 279-284
- 32. Jahng GH, Xu S, Weiner MW, Meyerhoff DJ, Park S, Schuff N. DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition
with evaluation of the intrinsic background gradients. Neuroradiology. 2011, 53: 749-762
- 31. Lim E, Lee S, Li E, Kim Y, Park S. Ghrelin protects spinal cord neurons against chronic glutamate-induced excitotoxicity via ERK1/2 and PI3K/Akt/GSK-3β pathways. Experimental Neurology. 2011 230: 114-122 (PMID: 21530509)
- 30. Lee JY, Chung H, Yoo YS, Oh YJ, Oh TH, Park Seungjoon. Yune TY. Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury. Endocrinology. 2010 Aug; 151(8):3518-3826 (PMID: 20444938)
- 29. Lee J, Lim E, Kim Y, Li E, Park Seungjoon. Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. Journal of Endocrinology. 2010 Jun; 205(3): 263-270. (PMID: 20351014)
- 28. Kim S, Moon M, Park Seungjoon. Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson’s disease. Journal of Endocrinology. 2009 Sep; 202(3): 431-439 (PMID: 19570816)
- 27. Moon M, Kim S, Hwang L, Park Seungjoon. Ghrelin regulates hippocampal neurogenesis in adult mice. Endocrine Journal. 2009 Jun; 56(3): 525-531.
- 26. Hwang S, Moon M, Kim S, Hwang L, Ahn KJ, Park Seungjoon. Neuroprotective Effect of Ghrelin is Associated with Decreased Expression of Prostate Apoptosis Response-4. Endocrine Journal. 2009 Apr 7; 56(4): 609-617. (PMID: 19352052)
- 25. Moon M, Kim HG, Hwang L, Seo JH, Kim S, Hwang S, Kim S, Lee D, Chung H, Oh MS, Lee KT, Park Seungjoon. Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease by blocking microglial activation. Neurotoxicity Research 2009 May; 15(4): 332-347 (PMID: 19384567)
- 24. Chung H, Seo S, Moon M, Park Seungjoon. Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3{beta} and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. Journal of Endocrinology. 2008 Sep 198(3): 511-521 (PMID: 18541646)
- 23. Seo S, Ju S, Chung H, Lee D, Park Seungjoon. Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats. Endocrine Journal. 2008 May 28; 55(5): 867-874.
- 22. Luque RM, Park Seungjoon, Kineman RD. Role of endogenous somatostatin in regulating GH output under basal conditions and in response to metabolic extremes. Molecular and Cellular Endocrinology. 2008 May 14;286(1-2):155-68. (PMID: 18258353)
- 21. Jung HJ, Kim EH, Mun JY, Park Seungjoon, Smith ML, Han SS, Seo YR (2007) Base Excision DNA Repair Defect in Gadd45a-Deficient Cells. Oncogene 26(54): 7517-7525
- 20. Chung H, Seo S, Moon M, Park Seungjoon. IGF-1 inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4. Journal of Endocrinology 2007 194:77-85 (PMID: 17592023)
- 19. Chung H, Kim E, Lee DH, Seo S, Ju S, Lee D, Kim H, Park Seungjoon. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 2007 148:148-159 (PMID: 17053024)
- 18. Luque RM, Park Seungjoon, Kineman RD. Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone (GHRH) in the fasted mouse; potential role of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH). Endocrinology 2007 148:300-309
- 17. Kim E, Sohn S, Lee M, Jung J, Kineman RD, Park Seungjoon. Differential responses of the GH-axis in two rat models of streptozotocin-induced insulinopenic diabetes. Journal of Endocrinology. 2006 188:263-270
- 16. Kim JY, Yim JH, Cho JH, Kim JH, Ko JH, Kim SM, Park Seungjoon, Park JH. Adrenomedullin regulates cellular glutathione content via modulation of r-glutamate-cysteine ligase catalytic subunit expression. Endocrinology. 2006 147:1357-1364
- 15. Park Seungjoon, Peng XD, Frohman LA, Kineman RD. Expression analysis of hypothalamic and pituitary contents of the GH axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice. Neuroendocrinology. 2005 81:360-371
- 14. Kim E, Sohn S, Lee M, Park C, Jung J, Park Seungjoon. Effect of gsp oncogene on somatostatin receptor subtype 1 and 2 mRNA levels in GHRH-responsive GH3 cells. Pituitary. 2005 8:155-162
- 13. Park C, Kim E, Sohn S, Yang I, Koh K, Oh S, Woo J, Kim S, Kim J, Kim Y, Oh K, Park S, Park Seungjoon. Acute hyperglycemia and activation of the beta-adrenergic system do not exhibit synergistic inhibitory actions on TRH-induced TSH secretion. Endocrine Journal. 2005 52:69-74
- 12. Luque RM, Kineman RD, Park Seungjoon, Peng XD, Gracia-Navarro F, Castano JP, Malagon MM. Homologous and heterologous regulation of pituitary receptors for ghrelin and growth hormone-releasing hormone. Endocrinology. 2004 Jul; 145(7): 3182-3189.
- 11. Park C, Yang I, Woo J, Kim S, Kim J, Kim Y, Sohn S, Kim E, Lee L, Park H, Jung J, Park Seungjoon. Somatostatin (SRIF) Receptor Subtype 2 and 5 Gene Expression in Growth Hormone-Secreting Pituitary Adenomas: The Relationship with Endogenous SRIF Activity and Response to Octreotide. Endocrine Journal 2004 51(2), 227-236
- 10. Luque RM, Park Seungjoon, Peng XD, Delgado E, Gracia-Navarro F, Kineman RD, Malagon MM, Castano JP. Homologous and heterologous in vitro regulation of pig pituitary somatostatin receptor subtypes, sst1, sst2 and sst5 mRNA. Journal of Molecular Endocrinology 2004 Apr; 32(2): 437-448
- 9. Park Seungjoon, Sohn S, Kineman RD. Fasting-induced changes in the hypothalamic-pituitary-GH axis in the absence of GH expression: Lessons from the spontaneous dwarf rat. Journal of Endocrinology 2004 Mar; 180(3): 369-378
- 8. Park Seungjoon, Kamegai J, Kineman RD. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effect. Neuroendocrinology 2003 Sep; 78(3):163-175,
- 7. Park C , Yang I , Woo J, Kim S, Kim J, Kim Y, Park Seungjoon. Acute Hyperglycemia and Activation of the b-Adrenergic System Exhibit Synergistic Inhibitory Actions on Growth Hormone (GH) Releasing Hormone-Induced GH Release. European Journal of Endocrinology 148(6):635-640, 2003
- 6. Wallenius K, Sjogren K, Peng X, Park Seungjoon, Wallenius V, Liu J-L, Umaerus M, Wennbo H, Isaksson O, Frohman LA, Kineman RD, Ohlsson C, Jansson J-O. Liver-derived insulin-like growth factor I regulates growth hormone secretion at the pituitary levels in mice. Endocrinology 2001 ; 142(11): 4762-4770,
- 5. Peng X, Park Seungjoon, Gadelha MR, Coschigano KT, Kopchick JJ, Frohman LA, Kineman RD. The GH-axis of GHR/BP gene-disrupted (GHR/BP-/-) and metallothionein-human GH-releasing hormone (MT-hGHRH) transgenic mice: Hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback. Endocrinology 142(3): 1117-1123, 2001 Mar.
- 4. Park Seungjoon, Kamegai J, Johnson TA, Frohman LA, Kineman RD. Modulation of pituitary somatostatin receptor subtype (sst1-5) messenger ribonucleic acid levels by changes in the growth hormone axis. Endocrinology 141:3556-3563, 2000.
- 3. Frohman LA, Kineman RD, Kamegai J, Park Seungjoon, Teixeria LT, Coschigano KT, Kopchick JJ. Secretatogues and the somatotrope: signaling and proliferation. Recent Progress in Hormone Research 55:269-91, 2000.
- 2. Yang I, Park Seungjoon, Woo J, Kim S, Kim J, Kim Y, Choi Y. Growth hormone response to the hypothalamic somatostatinergic activity in acromegalic patients. Journal of Clinical Endocrinology & Metabolisism 82:2492-2496, 1997.
- 1. Yang I, Park Seungjoon, Ryu M, Woo J, Kim S, Kim J, Kim Y, Choi Y. Characteristics of gsp-positive growth hormone-secreting pituitary tumors in Korean acromegalic patients. European Journal of Endocrinology 134:720-726, 1996.
저 서
- 분자의학연구기법 (고려의학, 1999년, 공저)
- 임상약리학 (대한의학서적, 2002년, 공역)
- 간호사를 위한 임상약리학 (범문사, 2005년, 공역)
- 임상간호 약물치료: 간호의 실제 (한우리, 2005년, 공역)
- Katzung 약리학 (고문사, 2006년 공역)