경희대학교 의과대학·의학전문대학원

- Biological Clock
- Molecular Neuroendocrinology
- Reproductive Physiology

- May 1994 ? Aug. 1998 : Researcher, Research Center for Cell Differentiation, Seoul National University (Prof. Kyungjin Kim)
- Jun. 1995 ? Dec. 1995 : Visiting Scientist, Abteilung f?r Klinische und Experimentelle Endocrinologie, University of G?ttingen, Germany (Prof. Wolfgang W. Wuttke)
- Sep. 1998 ? Mar. 2000 : Post-doctoral Researcher, Research Center for Cell Differentiation, Seoul National University (Prof. Kyungjin Kim)
- Mar. 2000 ? Sep. 2003 : Visiting Fellow, Steroid Hormones Section, Laboratory of Molecular and Cellular Biology, NIDDK, National Institutes of Health (Dr. S. Stoney Simons, Jr.)
- Oct. 2003 ? Feb. 2006 : Post-doctoral fellow, Institut de G?n?tique et de Biologie Mol?culaire et Cellulaire, CNRS, France (Dr. Paolo Sassone-Corsi)
- Mar. 2006 ? Dec. 2008 : Assistant Professor, Age-Related and Brain Diseases Research Center, Kyung Hee University
- Sep. 2007 ? Mar. 2010 : Assistant Professor, Department of Life and Nanopharmaceutical Science, Kyung Hee University
- Jan. 2009 ? Present : Assistant/Associate Professor, Department of Physiology, Kyung Hee University School of Medicine
- Jan. 2009 ? Present : Assistant/Associate Professor, Department of Neuroscience, Graduate School, Kyung Hee University

- Sep. 2006 ? Aug. 2009 Academic Committee, The Korean Society for Zoology (currently, The Korean Society for Integrative Biology)
- Sep. 2009 ? Aug. 2012 Treasurer, The Korean Society for Integrative Biology
- Sep. 2009 ? Aug. 2012 Winter Camp Organizing Committee, The Korean Society for Integrative Biology
- Jan. 2011 ? Dec. 2011 Election Commission member, The Korean Society for Molecular and Cellular Biology
- Nov. 2011 ? Jun. 2012 KSMCB Bioyouth Mentor
- Mar. 2012 - Present Academic Committee, The Korean Society of Developmental Biology
- Jan. 2014 ? Present Academic Award Committee/Winter Camp Organizing Committee, The Korean Society for Molecular and Cellular Biology

- 1. Cho, S. (1994) : Retinoic acid regulates GnRH release and GnRH gene expression in the rat hypothalamic fragments and GT1 cells in vitro. M. S. Dissertation (Seoul National University, Korea)
- 2. Cho, S. (1998) : Molecular regulation of hypothalamic and hippocampal neuronal cells: Autocrine regulation and action of retinoic acid. Ph. D. Dissertation (Seoul National University, Korea)
Original Articles
- 1. Cho B.N., Seong J.Y., Cho S., Kang H.M. and Kim K. (1994) Progesterone inhibits luteinizing hormone beta subunit (LHbeta) gene expression in the rat pituitary in a synergistic fashion with estrogen. Korean J. Zool. 37: 377-384.
- 2. Kang S.H., Seong J.Y., Cho S., Cho H. and Kim K. (1995) Acute increase in GABAergic neurotransmission exerts a stimulatory effect on GnRH gene expression in ovariectomized estrogen and progesterone treated adult female rats. Neuroendocrinology 61: 486-492.
- 3. Cho S., Han J., Sun W., Choi D., Kwon H.B., Jarry H., Wuttke W. and Kim K. (1997) Evidence for autocrine inhibition of gonadotropin-releasing hormone (GnRH) gene transcription by GnRH in hypothalamic GT1-1 neuronal cells. Mol. Brain Res. 50: 51-58.
- 4. Song E., Kang S.S., Cho S., Choe Y.S., Geum D., Choi D., and Kim K. (1997) Alteration of gonadotropin-releasing hormone and luteinizing hormone beta-subunit mRNA levels in neonatally estrogenized female rats. Korean J. Biol. Sci. 1: 596-602.
- 5. Cho S., Cho H., Geum D., and Kim K. (1998) Retinoic acid regulates GnRH release and GnRH gene expression in the rat hypothalamic fragments and hypothalamic GT1-1 neuronal cells in vitro. Mol. Brain Res. 54: 74-84.
- 6. Jung N., Sun W., Lee H., Cho S., Shim C., and Kim K. (1998) Gonadotropin-releasing hormone (GnRH) gene regulation by N-methyl-D-aspartic acid in GT1-1 neuronal cells: Differential involvement of c-fos and c-jun protooncogenes. Mol. Brain Res. 61: 162-169.
- 7. Han J., Cho S., Sun W., and Kim K. (1998) Autocrine regulation of gonadotropin-releasing hormone (GnRH) operates at multiple control levels of GnRH gene expression in GT1-1 neuronal cells. Korean J. Biol. Sci. 2: 483-488.
- 8. Chung J-J., Cho S., Kwon Y.K., Kim D.H., and Kim K. (2000) Activation of retinoic acid receptor ? induces proliferation of immortalized hippocampal progenitor cells. Mol. Brain Res. 83: 52-62.
- 9. Cho S., Chung J-J., Choe Y., Choi H-S., Kim D.H., Rhee K., and Kim K. (2001) A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene. Mol. Brain Res. 87: 204-213.
- 10. Cho S., Chung J-J., Han J., Lee B.J., Kim D.H., Rhee K., and Kim K. (2001) 9-cis-retinoic acid represses transcription of the gonadotropin- releasing hormone (GnRH) gene via proximal promoter region that is distinct from all- trans-retinoic acid response element. Mol. Brain Res. 87: 214-222.
- 11. Sun W., Lee H., Choe Y., Cho S., Kim D.H., and Kim K. (2001) Evidence for direct involvement of beta-catenin in phorbol ester-induced neurite outgrowth in GT1-1 hypothalamic neurons. J. Neuroendocrinol. 13: 249-260.
- 12. Kaul S., Blackford Jr. J.A., Cho S., and Simons Jr. S.S. (2002) Ubc9 is a GMEB-interacting protein that modifies the induction properties of glucocorticoid receptors. J. Biol. Chem. 277: 12541-12549.
- 13. Kim M.S., Hur M.K., Son Y.J., Park J-I. Chun S.Y., D’Elia A.V., Damante G., Cho S., Kim K., and Lee B.J. (2002) Regulation of adenylate cyclase-activating protein polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. J. Biol. Chem. 277: 36863-36871.
- 14. Kim G., Choe Y., Park J., Cho S. and Kim K. (2002) Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells. Mol. Brain Res. 109: 134-145.
- 15. Wang Q., Blackford J.A. Jr., Song L.N., Huang Y., Cho S., and Simons S.S. Jr. (2004) Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors. Mol. Endocrinol. 18:1376-1395.
- 16. Cho S., Kagan B.L., Blackford Jr. J.A., Szapary, D., and Simons Jr. S.S. (2005) Glucocorticoid receptor ligand binding domain is sufficient for the modulation of both the dose-response curve of receptor-agonist complexes and the partial agonist activity of receptor-antisteroid complexes by glucocorticoid receptors, coactivator TIF2, and Ubc9. Mol. Endocrinol. 19:290-311.
- 17. Cho S., Blackford Jr. J.A., Simons Jr. S.S. (2005) Role of activation function domains, DNA binding, and coactivators in the expression of partial agonist activity of glucocorticoid receptor complexes. Biochemistry 44:3547-3561.
- 18. Cho S., Yujnovsky I., Doi M., and Sassone-Corsi P. (2005) Transplantation of mouse embryo fibroblasts: an approach to study the physiological pathways linking the SCN and peripheral clocks. Methods Enzymol. 393:469-478.
- 19. Shim H.S., Kim H., Lee J., Son G.H., Cho S., Oh T.H., Kang S.H., Seen D-S., Lee K.H., and Kim K. (2007) Rapid activation of CLOCK by Ca2+-dependent PKC mediates resetting of the mammalian circadian clock. EMBO Rep 8:366-371.
- 20. Doi M, Cho S., Yujnovsky I., Hirayama J., Cermakian N., Cato A.C.B., and Sassone-Corsi P. (2007) Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in the mouse central pacemaker neurons. J. Biol. Rhythms 22:127-139.
- 21. Moon MJ, Oh DY, Moon JS, Kim DK, Hwang JI, Lee JY, Kim JI, Cho S, Kwon BH, Seong JY. (2007) Cloning and activation of the bullfrog apelin receptor: G(i/o) coupling and high affinity for [Pro(1)]apelin-13. Mol. Cell. Endocrinol. 277:51-60.
- 22. Hirayama J, Cho S, Sassone-Corsi P. (2007) Circadian control by reduction/oxidation pathway: Catalase represses light-dependent clock gene expression in the zebrafish. Proc. Natl. Acad. Sci. U. S. A. 104:15747-15752.
- 23. Son GH, Chung S, Choe HK, Kim HD, Baik SM, Lee H, Lee LW, Choi S, Sun W, Kim H, Cho S, Lee KH, Kim K (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production. Proc. Natl. Acad. Sci. U. S. A. 105:20970-20975.
- 24. Jeong JH, Cho S, Pak YK (2009) Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor gamma coactivator-1a (PGC-1a). Exp. Mol. Med. 41:406-416.
- 25. Sung YH, Shin MS, Cho S, Baik HH, Jin BK, Chang HK, Lee EK, Kim CJ (2010) Depression-like state in maternal rats induced by repeated separation of pups is accompanied by a decrease of cell proliferation and an increase of apoptosis in the hippocampus. Neurosci. Lett. 470:86-90.
- 26. Kim SE, Ko IG, Kim BK, Shin MS, Cho S, Kim CJ, Kim SH, Baek SS, Lee EK, Jee YS (2010) Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus. Exp. Gerontol. 45:357.
- 27. Kim SE, Ko IG, Kim BK, Sung YH, Shin MS, Cho S, Kim CJ, Kim KH, Lee KW, Kim DH (2010) Transplantation of human adipose-derived stem cells into the urethra ameliorates stress urinary incontinence and blunts the induction of c-Fos immunoreactivities in brain areas related to micturition in female rats. Anim. Cells Syst. 14: 237-244.
- 28. Ko IG, Kim SE, Kim JE, Sung YH, Kim BK, Shin MS, Cho S, Pak YK, Kim CJ and Cho HJ (2011) Hypothermia alleviates hypoxic ischemia-induced dopamine dysfunction and memory impairment in rats. Anim. Cells Syst. 15: 279-286.
- 29. Park N, Cheon S, Son GH, Cho S*, Kim K* (2012) Chronic circadian disturbance by a shortened light-dark cycle increases mortality. Neurobiol Aging 33: 1122.e11?1122.e22.
- 30. Kim JE, Ji ES, Seo JH, Lee MH, Cho S, Pak YK, Seo TB, Kim CJ (2012). Alcohol exposure induces depression-like behavior by decreasing hippocampal neuronal proliferation through inhibition of the BDNF-ERK pathway in gerbils. Anim Cells Syst. 16: 190-197.
- 31. Yoon JA, Han DH, Noh JY, Kim MH, Son GH, Kim K, Kim CJ, Pak YK, Cho S (2012) Meal time shift disturbs circadian rhythmicity with metabolic and behavioral alterations in mice. PLoS One 7(8): e44053.
- 32. Lee B, Sur B, Cho S, Shim I, Lee H, Ham DH (2012) Protective Effect of Phellodendri Cortex against Lipopolysaccharide-induced Memory Impairment in Rats. Anim Cells Syst. 16(4): 302-312.
- 33. Lee YJ, Han DH, Pak YK, Cho S (2012) Circadian regulation of LDLR promoter activity by CLOCK/BMAL1, Hes1 and Hes6. Exp Mol Med 44: 642-652.
- 34. Na J, Lee K, Kim HG, Shin JY, Na W, Jeong H, Lee JW, Cho S, Kim WS, Ju BG (2012) Role of type II protein arginine methyltransferase 5 in the regulation of circadian per1 gene. PLoS One 7(10): e48152.
- 35. Cheon S, Park N, Cho S, Kim K (2013) Glucocorticoid-mediated period 2 induction delays the phase of circadian rhythm. Nucleic Acids Res 41(12): 6161-6174.
- 36. Kim TS, Han DH, Lee YJ, Son GH, Kim K, Kim CJ, Cho S (2013) Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice. Anim Cells Syst 17(6): 397-405.
- 37. Kwak Y, Jeong J, Lee S, Park YU, Lee SA, Han DH, Kim JH, Ohshima T, Mikoshiba K, Suh YH, Cho S, Park SK (2013) Cdk5 regulates the function of CLOCK protein by direct phosphorylation. J Biol Chem 288(52): 36878-36889.
- 38. Han DH, Lee YJ, Kim K, Kim CJ, Cho S (2014) Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol Cell Endocrinol 383: 170-180.
- 39. Noh JY, Han DH, Kim MH, Ko IG, Kim SE, Park N, Choe HK, Kim KH, Kim K, Kim CJ, Cho S (2014) Presence of peripheral circadian oscillator in the tissues controlling voiding function in mice. Exp Mol Med 46:e81
- 40. Nam HJ, Boo K, Kim D, Han DH, Choe HK, Kim CR, Sun W, Kim H, Kim K, Lee H, Metzger E, Schuele R, Yoo SH, Takahashi JS, Cho S, Son GH, Baek SH (2014) Phosphorylation of Lysine-specific demethylase 1 by protein kinase Ca is crucial for circadian rhythmicity and phase resetting. Mol Cell 53: 791-805
Review Articles
- 1. Cho S. and Kim K. (1997) Molecular neuroendocrine regulation of GnRH and its receptor. J. Kor. Endocr. Soc. 12:493-503. (written in Korean)
- 2. Cho S., Choe Y., Han J., Lee S., Park J., Seong J.Y., and Kim K. (1999) Neuro- endocrine study on hypothalamic GnRH neuron. Zool. Soc. Kor. Newslett. 16:17-50. (written in Korean)
- 3. Cho S (2008) Oxidative stress and circadian rhythm. Biochem. Mol. Biol. News (June 2008) 1-8. (written in Korean)
- 4. Cho S, Han DH, and Kim DH (2011) Circadian rhythms in voiding function and dysfunction. Int. Neurourol. J. 15:2-3.
- 5. Noh JY, Han DH, Yoon JA, Kim MH, Kim SE, Ko IG, Kim KH, Kim CJ, Cho S (2011) Circadian rhythms in urinary functions: possible roles of circadian clocks? Int. Neurourol. J. 15:64-73.
저서
김경진, 조세형(2000) 신경호르몬. 대우학술총서 No. 476, 도서출판 아카넷, 서울
번역논문/역서
- 1. 조세형(1994) 생물학과 인간본성. 계간 과학사상(Science, Philosophy and Culture) 11: 66-86. ISSN: 1227-1330 (Original article: Hull DL, 1986. Biology and Human Nature. Proceedings of Philosophy of Science Association, 2:3-13).
- 2. 김은수 외(2008) 우리들의 성. 라이프사이언스, 서울. ISBN: 978-6154-025-4 (Original Textbook: Crooks R and Bauer K, Our Sexuality. 10th Ed. Thomson Learning Inc, 2008)
- 3. 백형환 외(2009) 리핀코트의 그림으로 보는 생화학. 신일북스, 서울. ISBN: 978-89-5702-208-5 (Original Textbook: Lippincott’s Illustrated Review: Biochemistry. 4th Ed. Lippincott Williams and Wilkins, 2009)
- 4. 이성호 외(2011) 웰치 성의 과학, 바이오사이언스, 서울. ISBN: 978-89-92709-42-2 (Original Textbook: Welch KJ, THINK Human Sexuality. Pearson Education Inc., 2011)
- 5. 조세형(2011) 생명의 떠오름: 세포는 어떻게 생명이 되는가? (다윈의 대답 제 8권) 이음, ISBN: 978-89-93116-46-0 0440 (Original Book: Maynard Smith J, Shaping Life: Genes, Embryos and Evolution. Yale University Press, 1998)
- 6. 조세형(2014) 빨강보기: 의식의 기원. 이음, 서울. ISBN: 978-89-93166-66-8 93400 (Original Book: Humphrey N, Seeing Red: A Study in Consciousness. Harvard University Press, 2006)