경희대학교 의과대학·의학전문대학원

- 미토콘드리아 기능손상에 의한 퇴행성질환 발병 기전연구
- Mitochondria and Metabolic Syndrome (DM, Obesity)
- Insulin Signaling Pathway and Food Intake
- Mitochondria and Neurodegeneration
- Chemical-induced Mitochondrial Damages
- Mitochondrial Medicine (Development of Therapeutics against Mitochondrial Dysfunctions)
- Molecular Physiology

- 1983 서울대학교 약학대학 학사 (B.S)
- 1985 서울대학교 약학대학 약물학 석사 (M.S.)
- 1991 미국 퍼듀대학교 생화학 박사 (Ph.D.)
- 1991-1995 미국 스탠포드 의과대학 Post-Doc & Research Associate
- 1995-1996 서울대학교 신의약품연구센터, 연수연구원
- 1996-2002 국립보건원 대사질환과, 보건연구관, 과장
- 2002-2007 울산의대 아산생명과학연구소, 부교수
- 2007-현재 경희대학교
- 2009 유니베라 생명약학 학술상
- 2005 로레알-여성생명과학기술 약진상
- 2001 과학기술진흥 유공자 과학기술부장관표창
- 1991-1993 스탠포드대학 Post-Doc Fellowshp
- 1983 서울대학교 우등졸업

- Experimental and Molecular Medicine (SCI Journal), Editorial Board
- Biomolecules and Therapeutics (SCIE Journal), Editorial Board
- 통합생화학분자생물학회, 종신회원
- 한국세포분자생물학회, 종신회원
- 대한 생리학회, 정회원
- 대한당뇨병학회, 정회원
- 대한 미토콘드리아 연구의학회, 종신회원
- 한국 지질동맥경화학회, 이사
- 한국 여성생명과학기술포럼, 고문, 2016년 회장
- 한국 여성과학기술단체 총연합회, 이사, 안전관리위원장
- 한국과학기술단체총연합회, 여성분과위원

- Representative papers of total 112 SCI papers (Youngmi Kim Pak, Pak YK)
- see google scholar: https://scholar.google.co.kr/citations?user=DSTBZ_sAAAAJ&hl=ko

1. Pak YK and Weiner H (1990) Import of chemically synthesized signal peptides into rat liver mitochondria. J. Biol. Chem. 265, 14298-14307
2. Pak YK, Kanuck MP, Berrios D, Cooper A, Briggs M, and Ellsworth J (1996) Activation of human LDL receptor gene expression by hepatocyte growth factor. J. Lip. Res. 37, 985-998.
3. Han CY, Park SY, and Pak YK. (2000) Role of endocytosis in the transactivation of nuclear factor-kappa B by oxidized low-density lipoprotein, Biochemical J. 350, 829-837
4. Park KS. Nam KJ, Kim JW, Lee YB. Jeong JK, Lee HK. and Pak YK. (2001) Depletion of mitochondrial DNA in SK-Hep1 cells decreases glucose uptake, Am. J. Physiol. Endocrinol. Metabol. 280(6), E1007-1014
5. Kim YS, Han CY, Kim SW, Kim JH, Lee SK, Jung DJ, Park, SY, Kang H, Choi HS, Lee JW, and Pak YK. (2001) The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kB in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7, J. Biol. Chem. 276, 33736-33740
6. Choi YS, Lee HK. and Pak YK. (2002) Characterization of the 5-flanking region of the rat gene and cDNA for mitochondrial transcription factor A (Tfam), Biochim. Biophys. Acta 1574, 200-204
7. Choi YS, Kim SH, Lee HK, Lee KU and Pak YK (2004) In vitro methylation of nuclear respiratory factor-1 binding site suppresses the promoter activity of mitochondrial transcription factor A. Biochem Biophys Res Commun. 314, 118-122
8. Lim S, Park SY, Kang KW, Kim ND, Lee KU, Lee HK, and Pak YK (2004) Inhibition of LPS-induced iNOS expression by a novel compound, mercaptopyrazine, through suppression of nuclear factor-kappa B binding to DNA. Biochem. Pharmacol. 68, 719-728
9. Oh J, Kim JW, Choi YS, Park JY, Kim SW, Park KK, and Pak YK (2005) Inhibition of low density lipoprotein receptor expression by long-term exposure of phorbol ester via p38 mitogen-activated protein kinase pathway, J of Cell. Biochem, 96, 786-794
10. Choi YS, Hong JM, Lim S, Ko KS, and Pak YK (2006) Impaired Coactivator Activity of the Gly482 Variant of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α (PGC-1α) on Mitochondrial Transcription Factor A (Tfam) Promoter, Biochem Biophys Res Commun. 344, 708-712
11. Kim MS*, Pak YK*, Jang PG, Namkung C, Choi YS, Jeon MJ, Han SM, Kim SW, Kim HS, Park JY, Kim YB, and Lee KU (2006) Role of forkhead transcription factor FOXO1 in the regulation of food intake and energy homeostasis, Nature Neuroscience, 9, 901-906
12. Chang E-J, Ha J, Oerlemans F, Lee YJ, Lee SW, Ryu J, Kim HJ, Lee Y, Kim H-M, Choi J-Y, Kim J Y, Shin CS, Pak YK, Tanaka S, Wieringa B, Lee ZH, and Kim HH (2008) Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption, Nature Medicine, 14(9):966-972
13. Lim S, Ahn SY, Song IC, Chung MH, Jang HC, Park KS, Lee KU, Pak YK*, and Lee HK* (2009) Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance, PLoS One 4(4): e5186 (* Co-corresponding) Highlighted in 1) Faculty of 1000 (FFa: 3). selected by Joan Ruderman 2) BRIC 한국을 빛내는 사람들
14. Park S-Y, Choi JH, Ryu HS, Pak YK, Park KS, Lee HK, and Lee W (2009) C1q tumor necrosis factor α-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase, J. Biol. Chem. 284, 27780-27789
15. Ahn SY, Choi YS, Koo HJ, Jeong JH, Park WH, Kim M, Piao Y, and Pak YK (2010) Mitochondrial dysfunction enhances the migration of vascular smooth muscles cells via suppression of Akt phosphorylation, BBA-General Subjects, 1800: 275-281
16. Park J, Pak YK*, Pak JJ* (2010) A microfabricated reservoir-type oxygen sensor for measuring the real-time cellular oxygen consumption rate at various conditions, Sensors and Actuators B-Chemical, 147: 263-269
17. Pak YK and Jeong JH (2010) Mitochondria: The secret chamber of therapeutic targets for age-dependent degenerative diseases, Biomolecules & Therapeutics, 18(3): 235-245
18. Choi YS, Jeong JH, Min H-K, Jung H-J, Hwang D, Lee S-W, and Pak YK (2011) Shot-gun proteomic analysis of mitochondrial D-loop DNA binding proteins: Identification of mitochondrial histones, Molecular BioSystems, 7: 1523-1536
19. Jeon J, Jeong J-H, Baek J-H, , Koo H-J, Park W-H, Yang J-S, Yu M-H, Kim S, Pak YK (2011) Network clustering revealed the systemic alterations of mitochondrial protein expression, PLoS Computational Biol. 7(6): e1002093
20. Piao Y, Kim H-G, Oh MS and Pak YK (2012) Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP+-induced mitochondrial dysfunctions in neuronal cells, BBA-General Subjects, 1820: 577-585
21. Park W-H and Pak YK (2011) Insulin-dependent suppression of cholesterol 7α-hydroxlase is a possible link between glucose and cholesterol metabolisms. Exp. Mol. Med. 43(10): 571-579
22. Koo H-J, Piao Y, and Pak YK (2012) ER stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells, Neuro-Signals, 20:265-280
23. Park, J, Nam H, Ahn SY, Pak YK, Pak JJ (2013) A reservoir-type oxygen sensor with 2x3 array for measuring cellular respiration levels, Sensors and Actuators B: Chemical 176: 913-920
24. Park W-H, Jun DW, Kim JT, Park H-K, Chang Y-S, Park KS, Lee HK, and Pak YK (2013) Novel cell-based assay reveals associations of circulating serum AhR-ligands with metabolic syndrome and mitochondrial dysfunction. BioFactors, 39(4), 494-504
25. Lim KS, Lim MH, Won Y-W, Kim JK, Kang YC, Park EJ, Chae J-W, Kim S-M, Ryu S-E, Pak YK, Kim Y-H (2013) Dual-mode enhancement of metallothionein proteins with cell transduction and retention peptide fusion, J Controlled Release, 171(2): 193-200
26. Lee EJ, Kang YC, Park W-H, Jeong JH, and Pak YK (2014) Negative transcriptional regulation of mitochondrial transcription factor A (TFAM) by nuclear TFAM, Biochem Biophys Res Commun. 450(1), 166-171
27. Kim J, Piao Y, Pak YK, Chung D, Han YM, Hong JS, Jun EJ, Shim JY, Choi J, Kim CJ. (2015) Umbilical cord mesenchymal stromal cells affected by gestational diabetes mellitus display premature aging and mitochondrial dysfunction. Stem Cells Dev. 24(5):575-586.
28. Roh E, Kwak SH, Jung HS, Cho YM, Pak YK, Park KS, Kim SY, Lee HK. (2015) Serum aryl hydrocarbon receptor ligand activity is associated with insulin resistance and resulting type 2 diabetes. Acta Diabetol. (Acta Diabetologica) Acta Diabetol. 52(3):489-495
29. Park WH, Kang S, Piao Y, Pak CJ, Kang MS, Oh MS, Kim J, and Pak YK (2015) Ethanol extract of Bupleurum falcatum Linne and saikosaponins inhibit neuroinflammation via inhibition of NF-κB, J. Ethnopharmacology, 174:37-44
30. Lind L, Lind PM, Lejonklou MH, Dunder L, Bergman Å, Guerrero-Bosagna C, Lampa E, Lee HK, Legler J, Nadal A, Pak YK, Phipps RP, Vandenberg LN, Zalko D, Ågerstrand M, Öberg M, Blumberg B, Heindel JJ, Birnbaum LS (2016) Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic, Environ Health Perspect 124:A81–A83
31. Jeong JH, Kang YC, Piao Y, Kang S, and Pak YK (2017) miR-24–mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway. Exp. Mol. Med, 49(4): e313
32. Park WH, Kang S, Lee HK, Salihovic S, van Bavel B, Lind PM, Pak YK*, Lind L.* (2017) Relationship between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs), Scientific Reports, 7(1):9383.
33. Lee H, Pak YK, Yeo EJ, Kim YS, Paik HY, Lee SK. (2018) It is time to integrate sex as a variable in preclinical and clinical studies Exp Mol Med. 50(7):82.
34. Kang YC, Son M, Kang S, Im S, Piao Y, Lim KS, Song MY, Park KS, Kim YH, Pak YK. (2018) Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson's disease models. Exp Mol Med. 50(8):105.
35. Jeong JS, Piao Y, Kang S, Son M, Kang YC, Du XF, Ryu J, Cho YW, Jiang HH, Oh MS, Hong SP, Oh YJ, Pak YK. (2018) Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease. Sci Rep. 2018 Oct 29;8(1):15953.