빌리루빈 대사과정
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- 작성자 : 선배
- 작성일 : 2005-11-20
- 조회 : 1,036회
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기초과정 학생이라고 생각하고 정말 쉽게 설명드립니다.
* 빌리루빈 형성에서 배출까지
1. in ER of RE cell
heme (mainly from RBC) → (by heme oxygenase) → biliverdin → (by biliverdin reductase) → bilirubin
2. in blood
bilirubin-albumin complex
3. in hepatocyte
bilirubin (B) → (by bilirubin glucuronyltransferase) → bilirubin monoglucuronide (BMG) → (by bilirubin glucuronyltransferase) → bilirubin diglucuronide (BDG)
4. in bile
BDG
5. in intestinal lumen
BDG → (by bacteria) → urobilinogen (UBG)→ (1) or (2).
(1) → to portal vein (reabsorption) → a) or b).
a) → to hepatocyte → to bile (reexcretion) → to intestine →(to 5.) : "cyclic circulation"
b) →(thru blood) → urobilin (in kidney) : "excretion" to urine
(2) →(by bacteria) → stercobilin (SB) : "excretion" to feces
--------------[가을동화 님의 邦都求?]--------------
빌리루빈 대사과정 쉅게 설명좀 해주세요
* 빌리루빈 형성에서 배출까지
1. in ER of RE cell
heme (mainly from RBC) → (by heme oxygenase) → biliverdin → (by biliverdin reductase) → bilirubin
2. in blood
bilirubin-albumin complex
3. in hepatocyte
bilirubin (B) → (by bilirubin glucuronyltransferase) → bilirubin monoglucuronide (BMG) → (by bilirubin glucuronyltransferase) → bilirubin diglucuronide (BDG)
4. in bile
BDG
5. in intestinal lumen
BDG → (by bacteria) → urobilinogen (UBG)→ (1) or (2).
(1) → to portal vein (reabsorption) → a) or b).
a) → to hepatocyte → to bile (reexcretion) → to intestine →(to 5.) : "cyclic circulation"
b) →(thru blood) → urobilin (in kidney) : "excretion" to urine
(2) →(by bacteria) → stercobilin (SB) : "excretion" to feces
--------------[가을동화 님의 邦都求?]--------------
빌리루빈 대사과정 쉅게 설명좀 해주세요