교수소개

처음 메뉴 임상교실

기초교실

기초교실

김경수 교수

영문이름 -
Kim, Kyoung Soo
교실 -
임상약리학교실
전공 -
분자면역학, 자가면역질환
연락처 -
02-961-9619
연구실 -
의학관 417-1
E-mail -
kimks@khu.ac.kr; labrea46@naver.com
홈페이지 -
- 1. To develop a therapeutic medicine to treat inflammatory diseases such as rheumatoid arthritis.
- 2. To find the new target molecules which are involved in the pathogenesis of rheumatoid arthritis.
- 3. To understand the pathogenesis of aging- or obesity-related diseases.
- 한국과학기술원 생물과학과 박사 졸업
- (주) 진로 종합연구소
- 아주대학교의료원 의과학연구소 내분비연구실
- University of Southern California Medical school, Division of Rheumatology
- 경희대학교 동서골관절연구원
- 경희대학교 의과대학 임상약리학교실
- 한국타우린연구회
- 대한류마티스학회
- 생화학분자생물학회
Selected Publication list

-40. Lee MK, Hwang M, Oh H, Kim KS* : Analysis of Sasang Constitutional Medicine as an Optimal Preventive Care Strategy for Hemophilia Patients. Biomed Res Int. 2020;4147803

-39. Choi HM, Doss HM, Kim KS* : Multifaceted Physiological Roles of Adiponectin in Inflammation and Diseases. Int J Mol Sci. 2020;21(4):1219

-38. Samarpita S, Kim JY, Rasool MK, Kim KS* : Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug. Arthritis Res Ther. 2020;22(1):16.

-37. Neog MK, Chung H, Jang MJ, Kim DJ, Lee SH, Kim KS* : Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex. Adv Exp Med Biol. 2019;1155:3-11.

-36. Cho KS, Neog MK, Kim JY, Yang HI, Kim KS* : Effects of Chronic Intake of a Low Concentration of Taurine on Physical Strength and Body Composition in Mice. Adv Exp Med Biol. 2019;1155:25-34.

-35. Kim KS*, Jang MJ, Fang S, Yoon SG, Kim IY, Seong JK, Yang HI, Hahm DH: Anti-obesity effect of taurine through inhibition of adipogenesis in white fat tissue but not in brown fat tissue in a high-fat diet-induced obese mouse model. Amino Acids. 2019, 51(2):245-254.

-34. Lee YH, Kim SY, Moon H, Seo JW, Kim DJ, Park SH, Kim YG, Moon JY, Kim JS, Jeong KH, Lim SJ, Kim CD, Park JB, Chung BH, Kim YH, Yang J, Yang HI, Kim KS*, Lee SH* (*Co-corresponding author) : Endocan as a marker of microvascular inflammation in kidney transplant recipients. Sci Rep 2019, 9(1):1854.

-33. Lee YA, Hahm DH, Kim JY, Sur B, Lee HM, Ryu CJ, Yang HI, Kim KS*: Potential therapeutic antibodies targeting specific adiponectin isoforms in rheumatoid arthritis. Arthritis Res Ther 2018, 2(1):245.

-32. Cho KS, Kim DJ, Shim B, Kim JY, Kang JM, Park SH, Lee SH, Yang HI, Kim KS*: An Investigation on the Therapeutic Effect of Thymosin beta4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice. Biomed Res Int 2018, 2018:3421568.

-31. Kim KS*, Yang HI: Thymosin beta4 in rheumatoid arthritis: Friend or foe. Biomed Rep 2017, 7(3):205-208.

-30. Kim KS*, Kim SH: Effect of N-(D-Ribopyranosyl) Taurine Sodium Salt on the Differentiation of Hu
man Preadipocytes and Expression of Adipokines Through Inhibition of STAT-3 Signaling in Differentiated Human Adipocytes. Adv Exp Med Biol 2017, 975:667-674

-29. Kim KS*, Bang E: Metabolomics Profiling of the Effects of Taurine Supplementation on Dyslipidemia in a High-Fat-Diet-Induced Rat Model by (1)H NMR Spectroscopy. Adv Exp Med Biol 2017, 975:329-336.

-28. Kim KS*, You JS, Kim JY, Chang KJ, Yoo MC, Song R, Lee YA, Lee SH, Hong SJ, Yang HI: Taurine ameliorates hypercholesterolemia but not obesity in rats fed a lard-based, high-fat diet. Adv Exp Med Biol 2015, 803:271-278.

- 27. Kim KS*, Lee YA, Ji HI, Song R, Kim JY, Lee SH, Hong SJ, Yoo MC, Yang HI: Increased expression of endocan in arthritic synovial tissues: effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes. Mol Med Rep 2015, 11(4):2695-2702.

- 26. Lee YA, Ji HI, Lee SH, Hong SJ, Yang HI, Chul Yoo M, Kim KS*: The role of adiponectin in the production of IL-6, IL-8, VEGF and MMPs in human endothelial cells and osteoblasts: implications for arthritic joints. Exp Mol Med 2014, 46:e72.

- 25. Ji HI, Lee SH, Song R, Yang HI, Lee YA, Hong SJ, Kim S, Park YB, Lee SK, Yoo MC, Kim KS*: Serum level of osteopontin as an inflammatory marker does not indicate disease activity or responsiveness to therapeutic treatments in patients with rheumatoid arthritis. Clin Rheumatol 2014, 33(3):397-402.

- 24. Kim KS*, Ji HI, Chung H, Kim C, Lee SH, Lee YA, Yang HI, Yoo MC, Hong SJ: Taurine chloramine modulates the expression of adipokines through inhibition of the STAT-3 signaling pathway in differentiated human adipocytes. Amino acids 2013, 45(6):1415-1422.

- 23. Song R, Choi HM, Yang HI, Yoo MC, Park YB, Kim KS*: Association between serum thymosin beta4 levels of rheumatoid arthritis patients and disease activity and response to therapy. Clin Rheumatol 2012, 31(8):1253-1258.

- 22. Park J, Choi HM, Yang HI, Yoo MC, Kim KS*: Increased expression of IL-1 receptors in response to IL-1beta may produce more IL-6, IL-8, VEGF, and PGE(2) in senescent synovial cells induced in vitro than in presenescent cells. Rheumatol Int 2012, 32(7):2005-2010.

- 21. Lee YA, Choi HM, Lee SH, Yang HI, Yoo MC, Hong SJ, Kim KS*: Synergy between adiponectin and interleukin-1beta on the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in fibroblast-like synoviocytes. Exp Mol Med 2012, 44(7):440-447.

- 20. Lee YA, Choi HM, Lee SH, Hong SJ, Yang HI, Yoo MC, Kim KS*: Hypoxia differentially affects IL-1beta-stimulated MMP-1 and MMP-13 expression of fibroblast-like synoviocytes in an HIF-1alpha-dependent manner. Rheumatology (Oxford) 2012, 51(3):443-450.

- 19. Kim KS*, Oh da H, Kim JY, Lee BG, You JS, Chang KJ, Chung HJ, Yoo MC, Yang HI, Kang JH, Hwang YC, Ahn KJ, Chung HY, Jeong IK: Taurine ameliorates hyperglycemia and dyslipidemia by reducing insulin resistance and leptin level in Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term diabetes. Exp Mol Med 2012, 44(11):665-673.

- 18. Kim KS*, Lee YA, Choi HM, Yoo MC, Yang HI: Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro-matrix metalloproteinase (MMP)-13. Rheumatol Int 2012, 32(10):3069-3075.

- 17. Kim KS*, Kim MH, Yeom M, Choi HM, Yang HI, Yoo MC, Hahm DH: Arthritic disease is more severe in older rats in a kaolin/carrageenan-induced arthritis model. Rheumatol Int 2012, 32(12):3875-3879.

- 16. Choi HM, Lee YA, Yang HI, Yoo MC, Kim KS*: Increased levels of thymosin beta4 in synovial fluid of patients with rheumatoid arthritis: association of thymosin beta4 with other factors that are involved in inflammation and bone erosion in joints. Int J Rheum Dis 2012, 14(4):320-324.

- 15. Kim KS*, Choi HM, Lee YA, Choi IA, Lee SH, Hong SJ, Yang HI, Yoo MC: Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis. Rheumatol Int 2011, 31(4):543-547.

- 14. Oh da H, Bang JS, Choi HM, Yang HI, Yoo MC, Kim KS*: Fetal bovine serum requirement for pyrrolidine dithiocarbamate-induced apoptotic cell death of MCF-7 breast tumor cells. Eur J Pharmacol 2010, 649(1-3):135-139.

- 13. Choi HM, Oh da H, Bang JS, Yang HI, Yoo MC, Kim KS*: Differential effect of IL-1beta and TNFalpha on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages. Rheumatol Int 2010, 30(8):1025-1033.

- 12. Lee YA, Yang HI, Park EK, Bang JS, Choi HM, Oh da H, Lee SH, Hong SJ, Jo YJ, Yoo MC, Kim KS*: Mizoribine may suppress bone erosion in patients with rheumatoid arthritis by inhibiting osteoclastogenesis. Eur J Pharmacol 2009, 605(1-3):46-48.

- 11. Kim KS*, Oh da H, Choi HM, Bang JS, Ryu CJ, Kim JH, Yoo MC, Yang HI: Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes. Eur J Pharmacol 2009, 613(1-3):167-175.

- 10. Choi HM, Lee YA, Lee SH, Hong SJ, Hahm DH, Choi SY, Yang HI, Yoo MC, Kim KS*: Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators. Arthritis Res Ther 2009, 11(6):R161.

- 9. Bang JS, Oh da H, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS*: Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther 2009, 11(2):R49.

- 8. Park EK, Rhee HI, Jung HS, Ju SM, Lee YA, Lee SH, Hong SJ, Yang HI, Yoo MC, Kim KS*: Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytother Res 2007, 21(8):746-750.

- 7. Park EK, Jung HS, Yang HI, Yoo MC, Kim C, Kim KS*: Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res 2007, 56(1):45-50.

- 6. Kim KS*, Park EK, Ju SM, Jung HS, Bang JS, Kim C, Lee YA, Hong SJ, Lee SH, Yang HI, Yoo MC: Taurine chloramine differentially inhibits matrix metalloproteinase 1 and 13 synthesis in interleukin-1beta stimulated fibroblast-like synoviocytes. Arthritis Res Ther 2007, 9(4):R80.

- 5. Park EK, Ryu MH, Kim YH, Lee YA, Lee SH, Woo DH, Hong SJ, Han JS, Yoo MC, Yang HI, Kim KS*: Anti-inflammatory effects of an ethanolic extract from Clematis mandshurica Rupr. J Ethnopharmacol 2006, 108(1):142-147.

- 4. Kim KS*, Rajagopal V, Gonsalves C, Johnson C, Kalra VK: A novel role of hypoxia-inducible factor in cobalt chloride- and hypoxia-mediated expression of IL-8 chemokine in human endothelial cells. J Immunol 2006, 177(10):7211-7224.

- 3. Kim KS*, Jacob N, Stohl W: In vitro and in vivo T cell oligoclonality following chronic stimulation with staphylococcal superantigens. Clin Immunol 2003, 108(3):182-189.

- 2. Kim KS*, Kang Y, Choi SE, Kim JH, Kim HM, Sun B, Jun HS, Yoon JW: Modulation of glucocorticoid-induced GAD expression in pancreatic beta-cells by transcriptional activation of the GAD67 promoter and its possible effect on the development of diabetes. Diabetes 2002, 51(9):2764-2772.

- 1. Kim KS*, Kim KH, Choi SE, Yoon JW, Kang Y: Soluble expression in Escherichia coli of murine endogenous retroviral transmembrane envelope protein having immunosuppressive activity. Protein Expr Purif 1999, 16(1):19-26.

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