교수소개

처음 메뉴 임상교실

기초교실

기초교실

윤태영[주임] 교수

영문이름 -
YUNE TAE YOUNG
교실 -
생화학&분자생물학교실
전공 -
신경생물학(척수손상, 척추관협착증, 뇌졸증 및 통증)
연락처 -
02-961-0968
연구실 -
의학관 1001호
E-mail -
tyune@khu.ac.kr
홈페이지 -
http://www.sciresearch.co.kr/
- 척수손상/뇌졸증/ALS: 세포사멸(신경세포/희소돌기아교세포) 메커니즘 연구
- 뇌혈관장벽 (Blood-brain barrier)/척수혈관장벽(blood-spinal cord barrier) 파괴 기전 연구
- 척수손상 후 epigenetic control의 기능 및 기전 연구
- 척수손상/척추관협착증에 따른 신경병증성 통증 (neuropathic pain) 연구
- 척수손상 후 stem cell transplantation을 통한 신경재생 연구
- 1994.7 - 2006.7 한국과학기술연구원 연구원, 선임연구원
- 2004.3 - 2005.2 Postdoctoral Fellow, Center for Molecular Neurobiology, Ohio State University, USA
- 2006.9 - 현재 조교수-교수(생화학분자생물학교실)/ 경희대학교 노인성 및 뇌질환연구소(소장), 경희대학교 대학원 기초의과학과
- 2009.7 - 2013.12 편집위원, Experimental Neurobiology
- 2012.6 - 2013.12 편집위원, International Scholarly Research Network (ISRN) Neuroscience
- 2013.4 - 현재 편집위원, Asian Journal of Neuroscience
- 2014.6 - 현재 편집위원, Neuroimmunoloy and Neuroinflammation
- 한국뇌신경과학회
- 한국분자세포생물학회
- 한국생화학분자생물학회
- 미국 신경과학회 정회원 (Society for Neuroscience)
- 1. Tae Y. Yune, Jee Y. Lee, Gil Y. Jung, Sun J. Kim, Hong K. Park, Mei H. Jiang, Young J. Oh, Young C. Kim, George J. Markelonis, and Tae H. Oh (2007). Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J. Neuroscience. 27 (29): 7751-7761.
- 2. Q. M. Li, C. Tep, T.Y. Yune, X. Z. Zhou, K. T.Uchida, k.P. Lu, and S. O. Yoon (2007). Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin-1 after spinal cord injury. J. Neuroscience. 27(31): 8395-8404.
- 3. Tae Y. Yune, Hong G. Park, Jee Y. Lee, and Tae H. Oh (2008). Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. J. Neurotrauma. 25(9):1121-1131
- 4. Tae Y. Yune, Jee Y. Lee, Mei H. Kang, Dae W. Kim, Su Y. Choi, and Tae H. Oh (2008). Systemic administration of PEP-1-SOD1 fusion protein improves functional recovery by inhibition of neuronal cell death after spinal cord injury. Free Radic. Biol. Med. 45(8):1190-1200
- 5. Tae Y. Yune, Jee Y. Lee, Chun M. Cui, Ho C Kim, and Tae H. Oh (2009). Neuroprotective effect of Scutellaria baicalensis on spinal cord injury in rats. J. Neurochem. 110(4):1276-1287
- 6. Doo C. Choi, Jee Y. Lee, Yoen J. Moon, Shin W. Kim, Tae H Oh, and Tae Y. Yune (2010). Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury. Neurobiol Dis. 39(3):272-282.
- 7. Jee Y. Lee, Hyun J. Chung, Young S. Yoo, Young J. Oh, Tae H. Oh, Seung J. Park, and Tae Y. Yune (2010). Inhibition of apoptotic cell death by ghrelin improves functional recovery after spinal cord injury. Endocrinology. 151(8):3815-3826.
- 8. Min Y. Song, Yune J. Moon, Seok K. Shin, Tae Y. Yune, and Kang S. Park. (2010). Contribution of the delayed-rectifier potassium channel Kv2.1 to acute spinal cord injury in rats. BMB Rep. 43(11):756-760
- 9. Jee Y. Lee, Tae H Oh, and Tae Y. Yune. (2011). Ghrelin inhibits hydrogen peroxide-induced apoptotic cell death of oligodendrocytes via ERK and p38MAPK signaling. Endocrinology. 152(6):2377-2386
- 10. Jung H. Kang, Mei H. Jiang, Hyun J. Min, Eun K. Jo, Soo J. Lee, Michael Karin, Tae Y. Yune, and Sung J. Lee (2011). IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. Eur J Immunol. 41(5):1266-1277
- 11. Youn J. Moon, Jee Y. Lee, Myung S. Oh, Youngmi K. Pak, Kang S. Park, Tae H. Oh, and Tae Y. Yune. (2012). Inhibiton of inflammation and oxidative stress by Angelica Dahuricae Radix extract decreases apoptotic cell death and improves functional recovery after spinal cord injury. J. Neurosci. Research. 90(1): 243-256
- 12. Jee Y. Lee, Hwang S. Kim, Hye Y. Choi, Tae H. Oh, Bong G. Ju, and Tae Y. Yune. (2012). Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury. J. Neurochemistry. 121(5):818-829.
- 13. KH. Lee, W. Na, Jee Y. Lee, JT Na, H Cho, HJ Wu, Tae Y. Yune, WS Kim and Bong G. Ju. (2012). Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury. J. Neurochemistry. 121(2):272-282.
- 14. Doo C. Choi, Jee Y. Lee, Eun J Lim, Hyung H. Baik, Tae H. Oh, and Tae Y. Yune (2012). Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats. Experimental Neurology. 236(2):268-282.
- 15. Jee Y. Lee, Soo Y. Choi, Tae H. Oh, and Tae Y. Yune (2012). 17β-Estradiol Inhibits Apoptotic Cell Death of Oligodendrocytes by Inhibiting RhoA-JNK3 Activation after Spinal Cord Injury. Endocrinology. 153(8):3815-3927.
- 16. Jee Y. Lee, Hwang S. Kim, Hye Y. Choi, Tae H. Oh, and Tae Y. Yune (2012). Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury. Brain. 135(Pt8):2375-2389.
- 17. Young C. Chung, Yoon S. Kim, Eu G. Bok, Tae Y. Yune, Byung K. Jin and Sung H. Maeng (2013). MMP-3 contributes to nigrostriatal dopaminergic neuronal loss via BBB damage and neuroinflammation in an MPTP mouse model of Parkinson’s disease. Mediators of Inflammation. Epub 2013 Jun 19.
- 18. Gil Y. Jung, Jee Y. Lee, Tae H. Oh and Tae Y. Yune (2013). An increase in voltage-gated sodium channel current elicits microglial activation followed inflammatory responses in vitro and in vivo after spinal cord injury. Glia. 61(11):1807-1821
- 19. Jee Y. Lee, Doo C. Choi, Tae H. Oh and Tae Y. Yune (2013). Analgesic effect by acupuncture is mediated by inhibiting JNK activation in astrocytes after spinal cord injury. Plos One. 8(9):e73948.
- 20. Jee Y. Lee, Se J. Maeng, So R. Kang, Hye Y. Choi, Tae H. Oh, Bong G. Ju and Tae Y. Yune (2014). Valproic acid protects motor neuron death by inhibiting oxidative stress and ER stress-mediated cytochrome c release after spinal cord injury. J. Neurotrauma. 31(6):582-594
- 21. Jee Y. Lee, Hyung E. Lee, So R. Kang, Hye Y. Choi, Jong H. Ryu and Tae Y. Yune (2014). Fluoxetine inhibits transient global ischemia-induced hippocampal neuronal death and memory impairment by preventing blood-brain barrier disruption. Neuropharmacology. 79(C):161-171
- 22. Sun Y. Jung, Dae Y. Kim, Tae Y. Yune, Dong H. Shin, Sang B. Baek and Chang J. Kim (2014). Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3/Akt pathway in rats. Experimental and Therapeutic Medicine. 7:587-59
- 23. Jee Y. Lee, Tae Y. Yune (2014) Ghrelin inhibits oligodendrocyte cell death by attenuating microglial activation. Endocrinology and Metabolism. 29(3):371-378
- 24. Jee Y. Lee, Hye Y. Choi, Hyune J. An, Bong G. Ju and Tae Y. Yune (2014) Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injury. American journal of pathology. 184(11):2985-3000
- 25. Jee Y. Lee , Hye Y. Choi, Won H. Na, Bong G. Ju and Tae Y. Yune (2014) Ghrelin inhibits BSCB disruption/hemorrhage by attenuating MMP-9 and SUR1/TrpM4 expression and activation after spinal cord injury. BBA - Molecular Basis of Disease. 1842(12 Pt A):2403-2412
- 26. Jee Y. Lee, So R. Kang, Tae Y. Yune (2015) Fluoxetine prevents oligodendrocyte cell death by inhibiting p38MAPK activation in activated microglia after spinal cord injury. J. Neurotrauma. 32(9):633-644.
- 27. Jee Y. Lee , Hye Y. Choi, Won H. Na, Bong G. Ju and Tae Y. Yune (2015). 17β-estradiol inhibits MMP-9 and SUR1/TrpM4 expression and activation and thereby attenuates BSCB disruption/hemorrhage after spinal cord injury in male rats. Endocrinology. 156(5):1838-1850
- 28. Jee Y. Lee , Hye Y. Choi, Tae Y. Yune (2015) MMP-3 secreted from endothelial cells of blood vessels after spinal cord injury activates microglia, leading to oligodendrocyte cell death. Neurobiol Dis. 82:141-151
- 29. See J. Park, Jee Y. Lee, SJ Kim, SY Choi, Tae Y. Yune and J H. Ryu (2015)Toll-like receptor-2 deficiency induces schizophrenia-like behaviors in mice. Scientific Reports. 17;5:8502
- 30. Won H. Na, Jee Y. Lee , Won S. Kim, Bong G. Ju and Tae Y. Yune (2015)17β-Estradiol ameliorates tight junction disruption via repression of MMP transcription. Mol Endocrinol.(2015) 29(9):1347-1361
- 31. B Kang, JA Oh, Jee Y. Lee, H Rhim, Tae Y. Yune and HY Park Choo (2015) 3-Benzamides and 3,4,5-trimethoxyphenyl amines as calcium channel blockers. Bioorg Med Chem. 23(18):6166-1672

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