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자유게시판

자유게시판

Harvard Medical School

페이지 정보

  • 작성자 : sgskim
  • 작성일 : 2007-12-20
  • 조회 : 1,551회

본문

아래 편지는 Harvard Medical School의 비뇨기과 연구소 소장이신 Dr. Michael R. Freeman 교수님으로부터 온 편지입니다.

김 자영 박사는 울산의대 생물학과를 졸업하고 우여곡절 끝에 경희의대 분자생물학교실에 와 6년 전에 경희의대 분자생물학교실에서 박사를 받았습니다. 박사 받고 Harvard Medical School의 Dr. Michael R. Freeman 교수님에게 Post-Doc으로 갈 때는 김 자영 박사 본인도 지도교수인 저도 김 자영 박사가 이렇게 성공할 수 있으리라고는 생각할 수 없었습니다.

6년이 지난 지금 김 자영 박사는 Harvard Medical School의 비뇨기과 교수로 채용되는 것 같습니다. 2년 전부터 instructor로 있었는데 이제는 자신의 연구비를 받아 직접 자신의 연구실을 운영하는 principal investigator가 되었다고 합니다. Harvard Medical School의 비뇨기과 교수가 되는 것입니다.

경희의대, 경희의학전문대학원 학생들은 꾸준히 노력하면 김 자영 박사보다 더 잘 할 수 있을 것으로 생각합니다. 많은 경희의대, 경희의학전문대학원 학생들이 좋은 연구 결과 (논문)을 발표하여 세계적으로 인정받는 의학자가 되기를 희망합니다.



Hi Dr. Kim, 

  Happy holidays!  I was very sorry to hear you weren't coming to Boston after all. I hope we have the chance to get together again soon. 

  Thank you for sending your student's CV. I would be interested in discussing further the possibility of Dr. Lim joining my lab.  Is there a possibility of partial or 1st year support for her from the Korean government? We are in a good funding situation at the moment, however the NIH budget is likely to remain flat over the 2008 fiscal year because of the troubled relationship at the moment between the Democratic Congress and President Bush. The president vetoed the NIH budget a few weeks ago, which contained a reasonable but modest increase over the previous year's funding levels. Those of us supported by NIH grants are being cautious about making commitments to new hires in this climate. We are hoping the future will be brighter when a new president takes over after next year's national elections. 

  That said, we have a lot of exciting work going on here. I've attached a recent paper in EMBO Journal. Jayoung published a first author paper in Cancer Research in October, describing the discovery of a lipid kinase that mediates EGFR trafficking to the nucleus. She is now leading a research team and has branched out into bladder cancer and interstitial cystitis. She recently was awarded a grant from the Interstitial Cystitis Association as PI and is a finalist in the competition for the Edwin Beer Scholar Awards given by the New York Academy of Medicine. In the first round, her proposal received the highest score in a field of about 25 superb applicants. This is a faculty transition award. 

  Let me know your thoughts, and best wishes for the New Year. 

Fondest regards, 

Michael


Harvard Medical School에서 지난 6년간 publish한 김 자영 선생 논문

1: Kim J, Jahng WJ, Di Vizio D, Lee JS, Jhaveri R, Rubin MA, Shisheva A, Freeman MR.
The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.
Cancer Res. 2007 Oct 1;67(19):9229-37.
PMID: 17909029 [PubMed - indexed for MEDLINE]

2: Kim J, Keay SK, Dimitrakov JD, Freeman MR.
p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells.
FEBS Lett. 2007 Aug 7;581(20):3795-9. Epub 2007 Jul 2.
PMID: 17628545 [PubMed - indexed for MEDLINE]

3: Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Boucher K, Solomon KR, Freeman MR.
Cholesterol sensitivity of endogenous and myristoylated Akt.
Cancer Res. 2007 Jul 1;67(13):6238-46.
PMID: 17616681 [PubMed - indexed for MEDLINE]

4: Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR.
The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer.
Mol Endocrinol. 2007 Sep;21(9):2056-70. Epub 2007 Jun 5.
PMID: 17550981 [PubMed - indexed for MEDLINE]

5: Park YS, Kim J, Misonou Y, Takamiya R, Takahashi M, Freeman MR, Taniguchi N.
Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.
Arterioscler Thromb Vasc Biol. 2007 Jun;27(6):1319-25. Epub 2007 Mar 15.
PMID: 17363696 [PubMed - indexed for MEDLINE]

6: Freeman MR, Cinar B, Kim J, Mukhopadhyay NK, Di Vizio D, Adam RM, Solomon KR.
Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes.
Steroids. 2007 Feb;72(2):210-7. Epub 2006 Dec 14. Review.
PMID: 17173942 [PubMed - indexed for MEDLINE]

7: Kim J, Adam RM, Freeman MR.
Trafficking of nuclear heparin-binding epidermal growth factor-like growth factor into an epidermal growth factor receptor-dependent autocrine loop in response to oxidative stress.
Cancer Res. 2005 Sep 15;65(18):8242-9.
PMID: 16166300 [PubMed - indexed for MEDLINE]

8: Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR.
Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts.
J Clin Invest. 2005 Apr;115(4):959-68. Epub 2005 Mar 17.
PMID: 15776112 [PubMed - indexed for MEDLINE]

9: Kim J, Lin J, Adam RM, Lamb C, Shively SB, Freeman MR.
An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding.
J Cell Biochem. 2005 Jan 1;94(1):39-49.
PMID: 15490481 [PubMed - indexed for MEDLINE]

10: Kim J, Adam RM, Solomon KR, Freeman MR.
Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cells.
Endocrinology. 2004 Feb;145(2):613-9. Epub 2003 Oct 16.
PMID: 14563701 [PubMed - indexed for MEDLINE]

11: Kim J, Freeman MR.
JNK/SAPK mediates doxorubicin-induced differentiation and apoptosis in MCF-7 breast cancer cells.
Breast Cancer Res Treat. 2003 Jun;79(3):321-8.
PMID: 12846416 [PubMed - indexed for MEDLINE]

12: Adam RM, Kim J, Lin J, Orsola A, Zhuang L, Rice DC, Freeman MR.
Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function.
Endocrinology. 2002 Dec;143(12):4599-608.
PMID: 12446587 [PubMed - indexed for MEDLINE]

13: Kim J, Adam RM, Freeman MR.
Activation of the Erk mitogen-activated protein kinase pathway stimulates neuroendocrine differentiation in LNCaP cells independently of cell cycle withdrawal and STAT3 phosphorylation.
Cancer Res. 2002 Mar 1;62(5):1549-54.
PMID: 11888934 [PubMed - indexed for MEDLINE]

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